1p7b

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[[Image:1p7b.gif|left|200px]]
 
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{{Structure
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==Crystal structure of an inward rectifier potassium channel==
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|PDB= 1p7b |SIZE=350|CAPTION= <scene name='initialview01'>1p7b</scene>, resolution 3.65&Aring;
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<StructureSection load='1p7b' size='340' side='right'caption='[[1p7b]], [[Resolution|resolution]] 3.65&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=K:POTASSIUM ION'>K</scene>
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<table><tr><td colspan='2'>[[1p7b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P7B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P7B FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.65&#8491;</td></tr>
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|GENE= chromosome 1 kirbac1.1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28450 Burkholderia pseudomallei])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p7b OCA], [https://pdbe.org/1p7b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p7b RCSB], [https://www.ebi.ac.uk/pdbsum/1p7b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p7b ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/P83698_BURPE P83698_BURPE]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p7/1p7b_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1p7b ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of an inward rectifier potassium channel'''
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==See Also==
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*[[Potassium channel 3D structures|Potassium channel 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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The KirBac1.1 channel belongs to the inward-rectifier family of potassium channels. Here we report the structure of the entire prokaryotic Kir channel assembly, in the closed state, refined to a resolution of 3.65 angstroms. We identify the main activation gate and structural elements involved in gating. On the basis of structural evidence presented here, we suggest that gating involves coupling between the intracellular and membrane domains. This further suggests that initiation of gating by membrane or intracellular signals represents different entry points to a common mechanistic pathway.
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==About this Structure==
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1P7B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P7B OCA].
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==Reference==
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Crystal structure of the potassium channel KirBac1.1 in the closed state., Kuo A, Gulbis JM, Antcliff JF, Rahman T, Lowe ED, Zimmer J, Cuthbertson J, Ashcroft FM, Ezaki T, Doyle DA, Science. 2003 Jun 20;300(5627):1922-6. Epub 2003 May 8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12738871 12738871]
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[[Category: Burkholderia pseudomallei]]
[[Category: Burkholderia pseudomallei]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Antcliff, J F.]]
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[[Category: Antcliff JF]]
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[[Category: Ashcroft, F M.]]
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[[Category: Ashcroft FM]]
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[[Category: Cuthbertson, J.]]
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[[Category: Cuthbertson J]]
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[[Category: Doyle, D A.]]
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[[Category: Doyle DA]]
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[[Category: Ezaki, T.]]
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[[Category: Ezaki T]]
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[[Category: Gulbis, J M.]]
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[[Category: Gulbis JM]]
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[[Category: Kuo, A.]]
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[[Category: Kuo A]]
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[[Category: Lowe, E D.]]
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[[Category: Lowe ED]]
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[[Category: Rahman, T.]]
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[[Category: Rahman T]]
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[[Category: Zimmer, J.]]
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[[Category: Zimmer J]]
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[[Category: K]]
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[[Category: cytosolic assembly]]
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[[Category: immunoglobulin fold]]
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[[Category: ion conduction]]
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[[Category: transmembrane helice]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:20:50 2008''
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Current revision

Crystal structure of an inward rectifier potassium channel

PDB ID 1p7b

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