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| | ==Open Structure of the BK channel Gating Ring== | | ==Open Structure of the BK channel Gating Ring== |
| - | <StructureSection load='3u6n' size='340' side='right' caption='[[3u6n]], [[Resolution|resolution]] 3.61Å' scene=''> | + | <StructureSection load='3u6n' size='340' side='right'caption='[[3u6n]], [[Resolution|resolution]] 3.61Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[3u6n]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U6N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U6N FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[3u6n]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U6N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U6N FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.61Å</td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Dr.74676, KCNMA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Danio rerio])</td></tr> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u6n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u6n RCSB], [http://www.ebi.ac.uk/pdbsum/3u6n PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u6n OCA], [https://pdbe.org/3u6n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u6n RCSB], [https://www.ebi.ac.uk/pdbsum/3u6n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u6n ProSAT]</span></td></tr> |
| | </table> | | </table> |
| - | <div style="background-color:#fffaf0;">
| + | == Function == |
| - | == Publication Abstract from PubMed == | + | [https://www.uniprot.org/uniprot/B7ZC96_DANRE B7ZC96_DANRE] |
| - | High-conductance voltage- and Ca(2+)-activated K(+) channels function in many physiological processes that link cell membrane voltage and intracellular Ca(2+) concentration, including neuronal electrical activity, skeletal and smooth muscle contraction, and hair cell tuning. Like other voltage-dependent K(+) channels, Ca(2+)-activated K(+) channels open when the cell membrane depolarizes, but in contrast to other voltage-dependent K(+) channels, they also open when intracellular Ca(2+) concentrations rise. Channel opening by Ca(2+) is made possible by a structure called the gating ring, which is located in the cytoplasm. Recent structural studies have defined the Ca(2+)-free, closed, conformation of the gating ring, but the Ca(2+)-bound, open, conformation is not yet known. Here we present the Ca(2+)-bound conformation of the gating ring. This structure shows how one layer of the gating ring, in response to the binding of Ca(2+), opens like the petals of a flower. The degree to which it opens explains how Ca(2+) binding can open the transmembrane pore. These findings present a molecular basis for Ca(2+) activation of K(+) channels and suggest new possibilities for targeting the gating ring to treat conditions such as asthma and hypertension.
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| - | Open structure of the Ca2+ gating ring in the high-conductance Ca2+-activated K+ channel.,Yuan P, Leonetti MD, Hsiung Y, MacKinnon R Nature. 2011 Dec 4;481(7379):94-7. doi: 10.1038/nature10670. PMID:22139424<ref>PMID:22139424</ref>
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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| - | </div>
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| | | | |
| | ==See Also== | | ==See Also== |
| - | *[[Potassium Channel|Potassium Channel]] | + | *[[Potassium channel 3D structures|Potassium channel 3D structures]] |
| - | == References ==
| + | |
| - | <references/>
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| | [[Category: Danio rerio]] | | [[Category: Danio rerio]] |
| - | [[Category: MacKinnon, R]] | + | [[Category: Large Structures]] |
| - | [[Category: Yuan, P]] | + | [[Category: MacKinnon R]] |
| - | [[Category: Potassium channel]] | + | [[Category: Yuan P]] |
| - | [[Category: Transport protein]]
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