3s11

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==Crystal structure of H5N1 influenza virus hemagglutinin, strain 437-10==
==Crystal structure of H5N1 influenza virus hemagglutinin, strain 437-10==
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<StructureSection load='3s11' size='340' side='right' caption='[[3s11]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='3s11' size='340' side='right'caption='[[3s11]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3s11]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S11 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3S11 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3s11]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S11 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S11 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3s12|3s12]], [[3s13|3s13]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3s11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s11 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3s11 RCSB], [http://www.ebi.ac.uk/pdbsum/3s11 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s11 OCA], [https://pdbe.org/3s11 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s11 RCSB], [https://www.ebi.ac.uk/pdbsum/3s11 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s11 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HEMA_I96A0 HEMA_I96A0] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3s11" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Hemagglutinin|Hemagglutinin]]
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*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Influenza a virus]]
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[[Category: Influenza A virus]]
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[[Category: DuBois, R M]]
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[[Category: Large Structures]]
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[[Category: Heath, R J]]
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[[Category: DuBois RM]]
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[[Category: Reddivari, M]]
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[[Category: Heath RJ]]
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[[Category: Russell, C J]]
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[[Category: Reddivari M]]
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[[Category: White, S W]]
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[[Category: Russell CJ]]
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[[Category: Zaraket, H]]
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[[Category: White SW]]
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[[Category: Hemagglutinin]]
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[[Category: Zaraket H]]
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[[Category: Viral envelope protein]]
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[[Category: Viral fusion protein]]
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[[Category: Viral protein]]
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Current revision

Crystal structure of H5N1 influenza virus hemagglutinin, strain 437-10

PDB ID 3s11

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