1pho

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[[Image:1pho.gif|left|200px]]
 
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{{Structure
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==CRYSTAL STRUCTURES EXPLAIN FUNCTIONAL PROPERTIES OF TWO E. COLI PORINS==
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|PDB= 1pho |SIZE=350|CAPTION= <scene name='initialview01'>1pho</scene>, resolution 3.0&Aring;
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<StructureSection load='1pho' size='340' side='right'caption='[[1pho]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1pho]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PHO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PHO FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pho OCA], [https://pdbe.org/1pho PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pho RCSB], [https://www.ebi.ac.uk/pdbsum/1pho PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pho ProSAT]</span></td></tr>
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}}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PHOE_ECOLI PHOE_ECOLI] Uptake of inorganic phosphate, phosphorylated compounds, and some other negatively charged solutes.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ph/1pho_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pho ConSurf].
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<div style="clear:both"></div>
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'''CRYSTAL STRUCTURES EXPLAIN FUNCTIONAL PROPERTIES OF TWO E. COLI PORINS'''
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==See Also==
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*[[Porin 3D structures|Porin 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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Porins form aqueous channels that aid the diffusion of small hydrophilic molecules across the outer membrane of Gram-negative bacteria. The crystal structures of matrix porin and phosphoporin both reveal trimers of identical subunits, each subunit consisting of a 16-stranded anti-parallel beta-barrel containing a pore. A long loop inside the barrel contributes to a constriction of the channel where the charge distribution affects ion selectivity. The structures explain at the molecular level functional characteristics and their alterations by known mutations.
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==About this Structure==
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1PHO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PHO OCA].
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==Reference==
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Crystal structures explain functional properties of two E. coli porins., Cowan SW, Schirmer T, Rummel G, Steiert M, Ghosh R, Pauptit RA, Jansonius JN, Rosenbusch JP, Nature. 1992 Aug 27;358(6389):727-33. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1380671 1380671]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Cowan, S W.]]
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[[Category: Cowan SW]]
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[[Category: Jansonius, J N.]]
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[[Category: Jansonius JN]]
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[[Category: Schirmer, T.]]
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[[Category: Schirmer T]]
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[[Category: outer membrane protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:24:31 2008''
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Current revision

CRYSTAL STRUCTURES EXPLAIN FUNCTIONAL PROPERTIES OF TWO E. COLI PORINS

PDB ID 1pho

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