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1ssz
From Proteopedia
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| - | ==Conformational | + | |
| - | <StructureSection load='1ssz' size='340' side='right' caption='[[1ssz]]' scene=''> | + | ==Conformational Mapping of Mini-B: An N-terminal/C-terminal Construct of Surfactant Protein B Using 13C-Enhanced Fourier Transform Infrared (FTIR) Spectroscopy== |
| + | <StructureSection load='1ssz' size='340' side='right'caption='[[1ssz]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1ssz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SSZ OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[1ssz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SSZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SSZ FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Infrared spectroscopy, 10 models</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ssz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ssz OCA], [https://pdbe.org/1ssz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ssz RCSB], [https://www.ebi.ac.uk/pdbsum/1ssz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ssz ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/PSPB_HUMAN PSPB_HUMAN] Defects in SFTPB are the cause of pulmonary surfactant metabolism dysfunction type 1 (SMDP1) [MIM:[https://omim.org/entry/265120 265120]; also called pulmonary alveolar proteinosis due to surfactant protein B deficiency. A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.<ref>PMID:7491219</ref> Genetic variations in SFTPB are a cause of susceptibility to respiratory distress syndrome in premature infants (RDS) [MIM:[https://omim.org/entry/267450 267450]. RDS is a lung disease affecting usually premature newborn infants. It is characterized by deficient gas exchange, diffuse atelectasis, high-permeability lung edema and fibrin-rich alveolar deposits called 'hyaline membranes'. Note=A variation Ile to Thr at position 131 influences the association between specific alleles of SFTPA1 and respiratory distress syndrome in premature infants.<ref>PMID:11063734</ref> |
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/PSPB_HUMAN PSPB_HUMAN] Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter. |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 17: | Line 19: | ||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 1ssz" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Alpha-lytic protease|Alpha-lytic protease]] | + | *[[Alpha-lytic protease 3D structures|Alpha-lytic protease 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Alig | + | [[Category: Homo sapiens]] |
| - | [[Category: Alonso | + | [[Category: Large Structures]] |
| - | [[Category: Bacon | + | [[Category: Alig T]] |
| - | [[Category: Braun | + | [[Category: Alonso C]] |
| - | [[Category: Gordon | + | [[Category: Bacon D]] |
| - | [[Category: Hernandez-Juviel | + | [[Category: Braun A]] |
| - | [[Category: Hong | + | [[Category: Gordon LM]] |
| - | [[Category: Sherman | + | [[Category: Hernandez-Juviel JM]] |
| - | [[Category: Walther | + | [[Category: Hong T]] |
| - | [[Category: Waring | + | [[Category: Sherman MA]] |
| - | [[Category: Zasadzinski | + | [[Category: Walther FJ]] |
| - | + | [[Category: Waring AJ]] | |
| - | + | [[Category: Zasadzinski JA]] | |
| - | + | ||
Current revision
Conformational Mapping of Mini-B: An N-terminal/C-terminal Construct of Surfactant Protein B Using 13C-Enhanced Fourier Transform Infrared (FTIR) Spectroscopy
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Categories: Homo sapiens | Large Structures | Alig T | Alonso C | Bacon D | Braun A | Gordon LM | Hernandez-Juviel JM | Hong T | Sherman MA | Walther FJ | Waring AJ | Zasadzinski JA
