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2yoa

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==Synaptotagmin-1 C2B domain with phosphoserine==
==Synaptotagmin-1 C2B domain with phosphoserine==
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<StructureSection load='2yoa' size='340' side='right' caption='[[2yoa]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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<StructureSection load='2yoa' size='340' side='right'caption='[[2yoa]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2yoa]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YOA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YOA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2yoa]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YOA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YOA FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1byn|1byn]], [[1k5w|1k5w]], [[1rsy|1rsy]], [[1tjm|1tjm]], [[1tjx|1tjx]], [[1uov|1uov]], [[1uow|1uow]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yoa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yoa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yoa RCSB], [http://www.ebi.ac.uk/pdbsum/2yoa PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yoa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yoa OCA], [https://pdbe.org/2yoa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yoa RCSB], [https://www.ebi.ac.uk/pdbsum/2yoa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yoa ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SYT1_RAT SYT1_RAT] May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2yoa" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Synaptotagmin 3D structures|Synaptotagmin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Bogaart, G van den]]
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[[Category: Diederichsen U]]
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[[Category: Diederichsen, U]]
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[[Category: Eggeling C]]
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[[Category: Eggeling, C]]
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[[Category: Fasshauer D]]
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[[Category: Fasshauer, D]]
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[[Category: Grubmuller H]]
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[[Category: Grubmuller, H]]
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[[Category: Hell SW]]
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[[Category: Hell, S W]]
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[[Category: Honigmann A]]
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[[Category: Honigmann, A]]
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[[Category: Iraheta E]]
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[[Category: Iraheta, E]]
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[[Category: Jahn R]]
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[[Category: Jahn, R]]
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[[Category: Kuhnel K]]
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[[Category: Kuhnel, K]]
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[[Category: Milovanovic D]]
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[[Category: Milovanovic, D]]
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[[Category: Muellar S]]
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[[Category: Muellar, S]]
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[[Category: Mueller V]]
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[[Category: Mueller, V]]
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[[Category: Risselada HJ]]
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[[Category: Risselada, H J]]
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[[Category: Van den Bogaart G]]
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[[Category: Signaling protein]]
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Current revision

Synaptotagmin-1 C2B domain with phosphoserine

PDB ID 2yoa

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