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3dxm

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==Structure of Bos taurus Arp2/3 Complex with Bound Inhibitor CK0993548==
==Structure of Bos taurus Arp2/3 Complex with Bound Inhibitor CK0993548==
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<StructureSection load='3dxm' size='340' side='right' caption='[[3dxm]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
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<StructureSection load='3dxm' size='340' side='right'caption='[[3dxm]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3dxm]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DXM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DXM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3dxm]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DXM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DXM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=N24:(2S)-2-(3-BROMOPHENYL)-3-(5-CHLORO-2-HYDROXYPHENYL)-1,3-THIAZOLIDIN-4-ONE'>N24</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3dxk|3dxk]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=N24:(2S)-2-(3-BROMOPHENYL)-3-(5-CHLORO-2-HYDROXYPHENYL)-1,3-THIAZOLIDIN-4-ONE'>N24</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dxm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3dxm RCSB], [http://www.ebi.ac.uk/pdbsum/3dxm PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dxm OCA], [https://pdbe.org/3dxm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dxm RCSB], [https://www.ebi.ac.uk/pdbsum/3dxm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dxm ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ARP3_BOVIN ARP3_BOVIN] Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dx/3dxm_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dx/3dxm_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dxm ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3dxm" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Actin-related protein 3D structures|Actin-related protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Hartman, J]]
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[[Category: Large Structures]]
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[[Category: Jia, Z]]
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[[Category: Hartman J]]
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[[Category: Nolen, B J]]
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[[Category: Jia Z]]
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[[Category: Pierce, D W]]
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[[Category: Nolen BJ]]
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[[Category: Pollard, T D]]
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[[Category: Pierce DW]]
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[[Category: Russell, A]]
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[[Category: Pollard TD]]
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[[Category: Sakowicz, R]]
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[[Category: Russell A]]
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[[Category: Tomasevic, N]]
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[[Category: Sakowicz R]]
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[[Category: Beta-propeller]]
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[[Category: Tomasevic N]]
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[[Category: Structural protein]]
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Current revision

Structure of Bos taurus Arp2/3 Complex with Bound Inhibitor CK0993548

PDB ID 3dxm

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