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3m5b

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==Crystal structure of the BTB domain from FAZF/ZBTB32==
==Crystal structure of the BTB domain from FAZF/ZBTB32==
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<StructureSection load='3m5b' size='340' side='right' caption='[[3m5b]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='3m5b' size='340' side='right'caption='[[3m5b]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3m5b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M5B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3M5B FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3m5b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M5B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M5B FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3m52|3m52]], [[3m4t|3m4t]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FAZF, TZFP, ZBTB32 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m5b OCA], [https://pdbe.org/3m5b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m5b RCSB], [https://www.ebi.ac.uk/pdbsum/3m5b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m5b ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3m5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m5b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3m5b RCSB], [http://www.ebi.ac.uk/pdbsum/3m5b PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ZBT32_HUMAN ZBT32_HUMAN] DNA-binding protein that binds to the to a 5'-TGTACAGTGT-3' core sequence. May function as a transcriptional transactivator and transcriptional repressor. Probably exerts its repressor effect by preventing GATA3 from binding to DNA. May play a role in regulating the differentiation and activation of helper T-cells (By similarity).<ref>PMID:10572087</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m5/3m5b_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m5/3m5b_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3m5b ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3m5b" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Pomroy, N C]]
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[[Category: Large Structures]]
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[[Category: Prive, G G]]
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[[Category: Pomroy NC]]
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[[Category: Stogios, P J]]
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[[Category: Prive GG]]
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[[Category: Alpha/beta protein]]
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[[Category: Stogios PJ]]
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[[Category: Btb domain]]
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[[Category: Btb/poz domain]]
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[[Category: Dna binding protein]]
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[[Category: Dna-binding]]
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[[Category: Fancc-interacting protein]]
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[[Category: Fanconi anemia zinc finger protein]]
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[[Category: Faxf]]
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[[Category: Fazf]]
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[[Category: Metal-binding]]
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[[Category: Nucleus]]
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[[Category: Poz domain]]
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[[Category: Protein-protein interaction domain]]
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[[Category: Repressor]]
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[[Category: Rog]]
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[[Category: Testis zinc finger protein]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Transcription regulator]]
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[[Category: Tzfp]]
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[[Category: Zbtb32]]
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[[Category: Zinc finger and btb domain-containing protein 32]]
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[[Category: Zinc-finger]]
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[[Category: Zinc-finger protein]]
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[[Category: Znf538]]
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Current revision

Crystal structure of the BTB domain from FAZF/ZBTB32

PDB ID 3m5b

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