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1q7j
From Proteopedia
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| - | [[Image:1q7j.jpg|left|200px]] | ||
| - | + | ==Structural Analysis of Integrin alpha IIb beta 3- Disintegrin with the AKGDWN Motif== | |
| - | + | <StructureSection load='1q7j' size='340' side='right'caption='[[1q7j]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1q7j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Calloselasma_rhodostoma Calloselasma rhodostoma]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q7J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q7J FirstGlance]. <br> | |
| - | | | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q7j OCA], [https://pdbe.org/1q7j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q7j RCSB], [https://www.ebi.ac.uk/pdbsum/1q7j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q7j ProSAT]</span></td></tr> | |
| - | + | </table> | |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/VM2RH_CALRH VM2RH_CALRH] Metalloproteinase rhodostoxin: snake venom metalloproteinase that impairs hemostasis in the envenomed animal (By similarity). Disintegrin rhodostomin: inhibit platelet aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Acts by inhibiting fibrinogen interaction with platelet receptors GPIIb/GPIIIa (ITGA2B/ITGB3). | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q7/1q7j_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q7j ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | + | ==See Also== | |
| - | + | *[[Disintegrin|Disintegrin]] | |
| - | + | __TOC__ | |
| - | == | + | </StructureSection> |
| - | + | ||
[[Category: Calloselasma rhodostoma]] | [[Category: Calloselasma rhodostoma]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Chen | + | [[Category: Chen CY]] |
| - | [[Category: Chen | + | [[Category: Chen YC]] |
| - | [[Category: Chuang | + | [[Category: Chuang WJ]] |
| - | [[Category: Shiu | + | [[Category: Shiu JH]] |
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Current revision
Structural Analysis of Integrin alpha IIb beta 3- Disintegrin with the AKGDWN Motif
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