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3n0f

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==Crystal Structure of Isoprene Synthase from Grey Poplar Leaves (Populus x canescens)==
==Crystal Structure of Isoprene Synthase from Grey Poplar Leaves (Populus x canescens)==
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<StructureSection load='3n0f' size='340' side='right' caption='[[3n0f]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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<StructureSection load='3n0f' size='340' side='right'caption='[[3n0f]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3n0f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Populus_tremula_x_populus_alba Populus tremula x populus alba]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N0F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3N0F FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3n0f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Populus_tremula_x_Populus_alba Populus tremula x Populus alba]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N0F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N0F FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3n0g|3n0g]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ispS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=80863 Populus tremula x Populus alba])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n0f OCA], [https://pdbe.org/3n0f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n0f RCSB], [https://www.ebi.ac.uk/pdbsum/3n0f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n0f ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Isoprene_synthase Isoprene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.27 4.2.3.27] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n0f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3n0f RCSB], [http://www.ebi.ac.uk/pdbsum/3n0f PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ISPS_POPCN ISPS_POPCN] Lyase that catalyzes the formation of isoprene from dimethylallyl diphosphate via a syn-periplanar elimination mechanism in which the diphosphate-leaving group serves as a general base.<ref>PMID:11506373</ref> <ref>PMID:20624401</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n0/3n0f_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n0/3n0f_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3n0f ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3n0f" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Isoprene synthase]]
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[[Category: Large Structures]]
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[[Category: Populus tremula x populus alba]]
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[[Category: Populus tremula x Populus alba]]
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[[Category: Christianson, D W]]
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[[Category: Christianson DW]]
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[[Category: Koksal, M]]
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[[Category: Koksal M]]
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[[Category: Ddxxd motif]]
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[[Category: Hemiterpene synthase]]
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[[Category: Lyase]]
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[[Category: Nse/dte motif]]
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[[Category: Terpene cyclase fold]]
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Current revision

Crystal Structure of Isoprene Synthase from Grey Poplar Leaves (Populus x canescens)

PDB ID 3n0f

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