3lm8
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==Crystal Structure of Thiamine pyrophosphokinase from Bacillus subtilis, Northeast Structural Genomics Consortium Target SR677== | ==Crystal Structure of Thiamine pyrophosphokinase from Bacillus subtilis, Northeast Structural Genomics Consortium Target SR677== | ||
| - | <StructureSection load='3lm8' size='340' side='right' caption='[[3lm8]], [[Resolution|resolution]] 2.60Å' scene=''> | + | <StructureSection load='3lm8' size='340' side='right'caption='[[3lm8]], [[Resolution|resolution]] 2.60Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3lm8]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3lm8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LM8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LM8 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=VIB:3-(4-AMINO-2-METHYL-PYRIMIDIN-5-YLMETHYL)-5-(2-HYDROXY-ETHYL)-4-METHYL-THIAZOL-3-IUM'>VIB</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lm8 OCA], [https://pdbe.org/3lm8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lm8 RCSB], [https://www.ebi.ac.uk/pdbsum/3lm8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lm8 ProSAT]</span></td></tr> | |
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/THIN_BACSU THIN_BACSU] Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lm/3lm8_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lm/3lm8_consurf.spt"</scriptWhenChecked> |
| - | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> |
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3lm8 ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Bacillus subtilis]] | [[Category: Bacillus subtilis]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Abashidze | + | [[Category: Abashidze M]] |
| - | [[Category: Acton | + | [[Category: Acton TB]] |
| - | [[Category: Ciccosanti | + | [[Category: Ciccosanti C]] |
| - | [[Category: Everett | + | [[Category: Everett JK]] |
| - | [[Category: Foote | + | [[Category: Foote EL]] |
| - | [[Category: Hunt | + | [[Category: Hunt JF]] |
| - | [[Category: Kuzin | + | [[Category: Kuzin A]] |
| - | [[Category: Mao | + | [[Category: Mao M]] |
| - | [[Category: Montelione | + | [[Category: Montelione GT]] |
| - | + | [[Category: Nair R]] | |
| - | [[Category: Nair | + | [[Category: Rost B]] |
| - | [[Category: Rost | + | [[Category: Seetharaman J]] |
| - | [[Category: Seetharaman | + | [[Category: Tong L]] |
| - | [[Category: Tong | + | [[Category: Wang H]] |
| - | [[Category: Wang | + | [[Category: Xiao R]] |
| - | [[Category: Xiao | + | |
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Current revision
Crystal Structure of Thiamine pyrophosphokinase from Bacillus subtilis, Northeast Structural Genomics Consortium Target SR677
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Categories: Bacillus subtilis | Large Structures | Abashidze M | Acton TB | Ciccosanti C | Everett JK | Foote EL | Hunt JF | Kuzin A | Mao M | Montelione GT | Nair R | Rost B | Seetharaman J | Tong L | Wang H | Xiao R
