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3n7o

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==X-ray structure of human chymase in complex with small molecule inhibitor.==
==X-ray structure of human chymase in complex with small molecule inhibitor.==
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<StructureSection load='3n7o' size='340' side='right' caption='[[3n7o]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='3n7o' size='340' side='right'caption='[[3n7o]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3n7o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N7O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3N7O FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3n7o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N7O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N7O FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=N7O:(S)-[(1S)-1-(5-CHLORO-1-BENZOTHIOPHEN-3-YL)-2-{[(E)-2-(3,4-DIFLUOROPHENYL)ETHENYL]AMINO}-2-OXOETHYL]METHYLPHOSPHINIC+ACID'>N7O</scene>, <scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">chymase (16-245), CMA1, CYH, CYM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=N7O:(S)-[(1S)-1-(5-CHLORO-1-BENZOTHIOPHEN-3-YL)-2-{[(E)-2-(3,4-DIFLUOROPHENYL)ETHENYL]AMINO}-2-OXOETHYL]METHYLPHOSPHINIC+ACID'>N7O</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chymase Chymase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.39 3.4.21.39] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n7o OCA], [https://pdbe.org/3n7o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n7o RCSB], [https://www.ebi.ac.uk/pdbsum/3n7o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n7o ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n7o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3n7o RCSB], [http://www.ebi.ac.uk/pdbsum/3n7o PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CMA1_HUMAN CMA1_HUMAN] Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n7/3n7o_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n7/3n7o_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3n7o ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3n7o" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Chymase]]
 
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Abad, M C]]
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[[Category: Large Structures]]
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[[Category: Bayoumy, S]]
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[[Category: Abad MC]]
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[[Category: Crysler, C]]
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[[Category: Bayoumy S]]
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[[Category: Deckman, I]]
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[[Category: Crysler C]]
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[[Category: Degaravilla, L]]
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[[Category: Deckman I]]
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[[Category: Greco, M N]]
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[[Category: Degaravilla L]]
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[[Category: Kervinen, J]]
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[[Category: Greco MN]]
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[[Category: Maryanoff, B E]]
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[[Category: Kervinen J]]
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[[Category: Spurlino, J]]
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[[Category: Maryanoff BE]]
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[[Category: Hydrolase]]
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[[Category: Spurlino J]]
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[[Category: Serine protease]]
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Current revision

X-ray structure of human chymase in complex with small molecule inhibitor.

PDB ID 3n7o

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