3m4t

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==Crystal structure of the BTB domain from Kaiso/ZBTB33, form I==
==Crystal structure of the BTB domain from Kaiso/ZBTB33, form I==
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<StructureSection load='3m4t' size='340' side='right' caption='[[3m4t]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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<StructureSection load='3m4t' size='340' side='right'caption='[[3m4t]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3m4t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M4T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3M4T FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3m4t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M4T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M4T FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3m8v|3m8v]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KAISO, ZBTB33, ZNF348 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m4t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m4t OCA], [https://pdbe.org/3m4t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m4t RCSB], [https://www.ebi.ac.uk/pdbsum/3m4t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m4t ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3m4t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m4t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3m4t RCSB], [http://www.ebi.ac.uk/pdbsum/3m4t PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KAISO_HUMAN KAISO_HUMAN] Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3'. Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2.<ref>PMID:11445535</ref> <ref>PMID:14527417</ref> <ref>PMID:15548582</ref> <ref>PMID:15817151</ref>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Chen, L]]
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[[Category: Large Structures]]
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[[Category: Prive, G G]]
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[[Category: Chen L]]
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[[Category: Stogios, P J]]
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[[Category: Prive GG]]
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[[Category: Activator]]
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[[Category: Stogios PJ]]
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[[Category: Btb domain]]
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[[Category: Btb/poz domain]]
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[[Category: Dna-binding]]
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[[Category: Kaiso]]
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[[Category: Metal-binding]]
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[[Category: Nucleus]]
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[[Category: Oligomeriation]]
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[[Category: Phosphoprotein]]
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[[Category: Poz domain]]
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[[Category: Protein-protein interaction domain]]
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[[Category: Repressor]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Transcriptional regulator kaiso]]
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[[Category: Wnt signaling pathway]]
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[[Category: Zbtb33]]
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[[Category: Zinc finger and btb domain-containing protein 33]]
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[[Category: Zinc-finger]]
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[[Category: Zinc-finger protein]]
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[[Category: Znf348]]
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Current revision

Crystal structure of the BTB domain from Kaiso/ZBTB33, form I

PDB ID 3m4t

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