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3nbz
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==Crystal structure of the HIV-1 Rev NES-CRM1-RanGTP nuclear export complex (crystal I)== | ==Crystal structure of the HIV-1 Rev NES-CRM1-RanGTP nuclear export complex (crystal I)== | ||
| - | <StructureSection load='3nbz' size='340' side='right' caption='[[3nbz]], [[Resolution|resolution]] 2.80Å' scene=''> | + | <StructureSection load='3nbz' size='340' side='right'caption='[[3nbz]], [[Resolution|resolution]] 2.80Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3nbz]] is a 6 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3nbz]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NBZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NBZ FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nbz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nbz OCA], [https://pdbe.org/3nbz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nbz RCSB], [https://www.ebi.ac.uk/pdbsum/3nbz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nbz ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/XPO1_MOUSE XPO1_MOUSE] Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase Ran in its active GTP-bound form. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap (By similarity).<ref>PMID:20921223</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 3nbz" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Exportin|Exportin]] | + | *[[Exportin 3D structures|Exportin 3D structures]] |
| - | *[[GTP-binding protein|GTP-binding protein]] | + | *[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Corsini | + | [[Category: Corsini L]] |
| - | [[Category: Deichsel | + | [[Category: Deichsel D]] |
| - | [[Category: Ficner | + | [[Category: Ficner R]] |
| - | [[Category: Gorlich | + | [[Category: Gorlich D]] |
| - | [[Category: Guttler | + | [[Category: Guttler T]] |
| - | [[Category: Madl | + | [[Category: Madl T]] |
| - | [[Category: Monecke | + | [[Category: Monecke T]] |
| - | [[Category: Neumann | + | [[Category: Neumann P]] |
| - | [[Category: Sattler | + | [[Category: Sattler M]] |
| - | + | ||
| - | + | ||
Current revision
Crystal structure of the HIV-1 Rev NES-CRM1-RanGTP nuclear export complex (crystal I)
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Categories: Homo sapiens | Large Structures | Mus musculus | Corsini L | Deichsel D | Ficner R | Gorlich D | Guttler T | Madl T | Monecke T | Neumann P | Sattler M
