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3j1w

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==A refined model of the prototypical Salmonella typhimurium T3SS basal body reveals the molecular basis for its assembly==
==A refined model of the prototypical Salmonella typhimurium T3SS basal body reveals the molecular basis for its assembly==
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<StructureSection load='3j1w' size='340' side='right' caption='[[3j1w]]' scene=''>
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<SX load='3j1w' size='340' side='right' viewer='molstar' caption='[[3j1w]], [[Resolution|resolution]] 11.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3j1w]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_typhimurium"_loeffler_1892 "bacillus typhimurium" loeffler 1892]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J1W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3J1W FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3j1w]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J1W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J1W FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4g08|4g08]], [[4g1i|4g1i]], [[3j1v|3j1v]], [[3j1x|3j1x]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 11.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3j1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j1w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3j1w RCSB], [http://www.ebi.ac.uk/pdbsum/3j1w PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j1w OCA], [https://pdbe.org/3j1w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j1w RCSB], [https://www.ebi.ac.uk/pdbsum/3j1w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j1w ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/PRGH_SALTY PRGH_SALTY] Required for invasion of epithelial cells.
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Type III secretion systems (T3SSs) are essential virulence factors used by many Gram-negative bacteria to inject proteins that make eukaryotic host cells accessible to invasion. The T3SS core structure, the needle complex (NC), is a ~3.5 megadalton-sized, oligomeric, membrane-embedded complex. Analyzing cryo-electron microscopy images of top views of NCs or NC substructures from Salmonella typhimurium revealed a 24-fold symmetry for the inner rings and a 15-fold symmetry for the outer rings, giving an overall C3 symmetry. Local refinement and averaging showed the organization of the central core and allowed us to reconstruct a subnanometer composite structure of the NC, which together with confident docking of atomic structures reveal insights into its overall organization and structural requirements during assembly.
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Three-dimensional model of Salmonella's needle complex at subnanometer resolution.,Schraidt O, Marlovits TC Science. 2011 Mar 4;331(6021):1192-5. PMID:21385715<ref>PMID:21385715</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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__TOC__
__TOC__
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</StructureSection>
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</SX>
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[[Category: Bacillus typhimurium loeffler 1892]]
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[[Category: Large Structures]]
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[[Category: Baker, D]]
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[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
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[[Category: Sgourakis, N G]]
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[[Category: Baker D]]
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[[Category: Strynadka, N C.J]]
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[[Category: Sgourakis NG]]
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[[Category: Worrall, L J]]
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[[Category: Strynadka NCJ]]
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[[Category: Cell invasion]]
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[[Category: Worrall LJ]]
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[[Category: T3ss]]
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Current revision

A refined model of the prototypical Salmonella typhimurium T3SS basal body reveals the molecular basis for its assembly

3j1w, resolution 11.70Å

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