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3n8e
From Proteopedia
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==Substrate binding domain of the human Heat Shock 70kDa protein 9 (mortalin)== | ==Substrate binding domain of the human Heat Shock 70kDa protein 9 (mortalin)== | ||
| - | <StructureSection load='3n8e' size='340' side='right' caption='[[3n8e]], [[Resolution|resolution]] 2.80Å' scene=''> | + | <StructureSection load='3n8e' size='340' side='right'caption='[[3n8e]], [[Resolution|resolution]] 2.80Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3n8e]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3n8e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N8E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N8E FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n8e OCA], [https://pdbe.org/3n8e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n8e RCSB], [https://www.ebi.ac.uk/pdbsum/3n8e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n8e ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GRP75_HUMAN GRP75_HUMAN] Implicated in the control of cell proliferation and cellular aging. May also act as a chaperone. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n8/3n8e_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n8/3n8e_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3n8e ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Berglund | + | [[Category: Berglund H]] |
| - | [[Category: Bountra | + | [[Category: Bountra C]] |
| - | [[Category: Collins | + | [[Category: Collins R]] |
| - | [[Category: Edwards | + | [[Category: Edwards AM]] |
| - | [[Category: Flodin | + | [[Category: Flodin S]] |
| - | [[Category: Flores | + | [[Category: Flores A]] |
| - | [[Category: Graslund | + | [[Category: Graslund S]] |
| - | [[Category: Hammarstrom | + | [[Category: Hammarstrom M]] |
| - | [[Category: Johansson | + | [[Category: Johansson I]] |
| - | [[Category: Karlberg | + | [[Category: Karlberg T]] |
| - | [[Category: Kotenyova | + | [[Category: Kotenyova T]] |
| - | [[Category: Moche | + | [[Category: Moche M]] |
| - | [[Category: Nordlund | + | [[Category: Nordlund P]] |
| - | [[Category: Nyman | + | [[Category: Nyman T]] |
| - | [[Category: Persson | + | [[Category: Persson C]] |
| - | + | [[Category: Schuler H]] | |
| - | [[Category: Schuler | + | [[Category: Schutz P]] |
| - | [[Category: Schutz | + | [[Category: Siponen MI]] |
| - | [[Category: Siponen | + | [[Category: Svensson L]] |
| - | [[Category: Svensson | + | [[Category: Thorsell AG]] |
| - | [[Category: Thorsell | + | [[Category: Tresaugues L]] |
| - | [[Category: Tresaugues | + | [[Category: Wahlberg E]] |
| - | [[Category: Wahlberg | + | [[Category: Weigelt J]] |
| - | [[Category: Weigelt | + | [[Category: Welin M]] |
| - | [[Category: Welin | + | [[Category: Wisniewska M]] |
| - | [[Category: Wisniewska | + | [[Category: Van der Berg S]] |
| - | [[Category: | + | |
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Current revision
Substrate binding domain of the human Heat Shock 70kDa protein 9 (mortalin)
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Berglund H | Bountra C | Collins R | Edwards AM | Flodin S | Flores A | Graslund S | Hammarstrom M | Johansson I | Karlberg T | Kotenyova T | Moche M | Nordlund P | Nyman T | Persson C | Schuler H | Schutz P | Siponen MI | Svensson L | Thorsell AG | Tresaugues L | Wahlberg E | Weigelt J | Welin M | Wisniewska M | Van der Berg S
