3ld1

<StructureSection load='3ld1' size='340' side='right'caption='[[3ld1]], [[Resolution|resolution]] 2.50&Aring;' scene=''>

<table><tr><td colspan='2'>[[3ld1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Avian_infectious_bronchitis_virus_(strain_M41) Avian infectious bronchitis virus (strain M41)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LD1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LD1 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.498&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ld1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ld1 OCA], [https://pdbe.org/3ld1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ld1 RCSB], [https://www.ebi.ac.uk/pdbsum/3ld1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ld1 ProSAT]</span></td></tr>

== Function ==

[https://www.uniprot.org/uniprot/R1A_IBVM R1A_IBVM] The papain-like proteinase (PL-PRO) is responsible for the cleavages located at the N-terminus of replicase polyprotein. Activity of PL-PRO is dependent on zinc (By similarity). The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK. Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function (By similarity). The peptide p16 might be involved in the EGF signaling pathway (By similarity). Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter (By similarity). Nsp9 is a ssRNA-binding protein (By similarity).

[[Category: Large Structures]]

[[Category: Bartlam M]]

[[Category: Chen C]]

[[Category: Cong L]]

[[Category: Fu J]]

[[Category: Rao Z]]

[[Category: Tang H]]

[[Category: Wei L]]

[[Category: Xu Y]]

[[Category: Yang A]]