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3odx
From Proteopedia
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==Crystal Structure of an N-terminally Truncated Linker-DH/PH Domains of p115-RhoGEF== | ==Crystal Structure of an N-terminally Truncated Linker-DH/PH Domains of p115-RhoGEF== | ||
| - | <StructureSection load='3odx' size='340' side='right' caption='[[3odx]], [[Resolution|resolution]] 3.20Å' scene=''> | + | <StructureSection load='3odx' size='340' side='right'caption='[[3odx]], [[Resolution|resolution]] 3.20Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3odx]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3odx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ODX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ODX FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2Å</td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3odx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3odx OCA], [https://pdbe.org/3odx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3odx RCSB], [https://www.ebi.ac.uk/pdbsum/3odx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3odx ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ARHG1_HUMAN ARHG1_HUMAN] Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.<ref>PMID:8810315</ref> <ref>PMID:9641915</ref> <ref>PMID:9641916</ref> <ref>PMID:20098430</ref> | ||
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| + | ==See Also== | ||
| + | *[[Rho guanine nucleotide exchange factor 3D structures|Rho guanine nucleotide exchange factor 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Chen Z]] |
| - | [[Category: | + | [[Category: Guo L]] |
| - | [[Category: | + | [[Category: Sprang SR]] |
| - | [[Category: | + | [[Category: Sternweis PC]] |
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Current revision
Crystal Structure of an N-terminally Truncated Linker-DH/PH Domains of p115-RhoGEF
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