3pa8

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==Structure of the C. difficile TcdB cysteine protease domain in complex with a peptide inhibitor==
==Structure of the C. difficile TcdB cysteine protease domain in complex with a peptide inhibitor==
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<StructureSection load='3pa8' size='340' side='right' caption='[[3pa8]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='3pa8' size='340' side='right'caption='[[3pa8]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3pa8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_difficile_630 Clostridium difficile 630]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PA8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PA8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3pa8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridioides_difficile_630 Clostridioides difficile 630]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PA8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PA8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=621:N-ACETYLGLYCYL-N-[(3S)-1-HYDROXY-5-METHYL-2-OXOHEXAN-3-YL]-L-SERINAMIDE'>621</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=IHP:INOSITOL+HEXAKISPHOSPHATE'>IHP</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CD0660, tcdB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272563 Clostridium difficile 630])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=621:N-ACETYLGLYCYL-N-[(3S)-1-HYDROXY-5-METHYL-2-OXOHEXAN-3-YL]-L-SERINAMIDE'>621</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=IHP:INOSITOL+HEXAKISPHOSPHATE'>IHP</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pa8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pa8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pa8 RCSB], [http://www.ebi.ac.uk/pdbsum/3pa8 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pa8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pa8 OCA], [https://pdbe.org/3pa8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pa8 RCSB], [https://www.ebi.ac.uk/pdbsum/3pa8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pa8 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q189K3_CLOD6 Q189K3_CLOD6]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3pa8" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Clostridium difficile 630]]
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[[Category: Clostridioides difficile 630]]
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[[Category: Garcia, K C]]
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[[Category: Large Structures]]
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[[Category: Lupardus, P J]]
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[[Category: Garcia KC]]
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[[Category: Clan cd cysteine protease]]
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[[Category: Lupardus PJ]]
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[[Category: Protease]]
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[[Category: Toxin]]
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[[Category: Toxin-peptide inhibitor complex]]
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Current revision

Structure of the C. difficile TcdB cysteine protease domain in complex with a peptide inhibitor

PDB ID 3pa8

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