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3nsw

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==Crystal Structure of Ancylostoma ceylanicum Excretory-Secretory Protein 2==
==Crystal Structure of Ancylostoma ceylanicum Excretory-Secretory Protein 2==
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<StructureSection load='3nsw' size='340' side='right' caption='[[3nsw]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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<StructureSection load='3nsw' size='340' side='right'caption='[[3nsw]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3nsw]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Ancylostoma_ceylanicum Ancylostoma ceylanicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NSW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NSW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3nsw]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Ancylostoma_ceylanicum Ancylostoma ceylanicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NSW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NSW FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ES-2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=53326 Ancylostoma ceylanicum])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nsw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nsw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nsw RCSB], [http://www.ebi.ac.uk/pdbsum/3nsw PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nsw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nsw OCA], [https://pdbe.org/3nsw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nsw RCSB], [https://www.ebi.ac.uk/pdbsum/3nsw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nsw ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q6R7N7_9BILA Q6R7N7_9BILA]
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Hookworms are human parasites that have devastating effects on global health, particularly in underdeveloped countries. Ancylostoma ceylanicum infects humans and animals, making it a useful model organism to study disease pathogenesis. A. ceylanicum excretory-secretory protein 2 (AceES-2), a highly immunoreactive molecule secreted by adult worms at the site of intestinal attachment, is partially protective when administered as a mucosal vaccine against hookworm anemia. The crystal structure of AceES-2 determined at 1.75 A resolution shows that it adopts a netrin-like fold similar to that found in tissue inhibitors of matrix metalloproteases (TIMPs) and in complement factors C3 and C5. However, recombinant AceES-2 does not significantly inhibit the 10 most abundant human matrix metalloproteases or complement-mediated cell lysis. The presence of a highly acidic surface on AceES-2 suggests that it may function as a cytokine decoy receptor. Several small nematode proteins that have been annotated as TIMPs or netrin-domain-containing proteins display sequence homology in structurally important regions of AceES-2's netrin-like fold. Together, our results suggest that AceES-2 defines a novel family of nematode netrin-like proteins, which may function to modulate the host immune response to hookworm and other parasites.
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Ancylostoma ceylanicum excretory-secretory protein 2 adopts a netrin-like fold and defines a novel family of nematode proteins.,Kucera K, Harrison LM, Cappello M, Modis Y J Mol Biol. 2011 Apr 22;408(1):9-17. Epub 2011 Feb 23. PMID:21352830<ref>PMID:21352830</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Ancylostoma ceylanicum]]
[[Category: Ancylostoma ceylanicum]]
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[[Category: Kucera, K]]
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[[Category: Large Structures]]
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[[Category: Modis, Y]]
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[[Category: Kucera K]]
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[[Category: Excretory-secretory protein]]
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[[Category: Modis Y]]
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[[Category: Hookworm]]
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[[Category: Immune system]]
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[[Category: Immunomodulator]]
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[[Category: Merohedral twinning]]
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[[Category: Netrin domain]]
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Current revision

Crystal Structure of Ancylostoma ceylanicum Excretory-Secretory Protein 2

PDB ID 3nsw

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