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3obq

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==Crystal Structure of the Tsg101 UEV domain in complex with a human HRS PSAP peptide==
==Crystal Structure of the Tsg101 UEV domain in complex with a human HRS PSAP peptide==
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<StructureSection load='3obq' size='340' side='right' caption='[[3obq]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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<StructureSection load='3obq' size='340' side='right'caption='[[3obq]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3obq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OBQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OBQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3obq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OBQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OBQ FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1m4q|1m4q]], [[3obu|3obu]], [[3obx|3obx]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TSG101 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3obq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3obq OCA], [https://pdbe.org/3obq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3obq RCSB], [https://www.ebi.ac.uk/pdbsum/3obq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3obq ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3obq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3obq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3obq RCSB], [http://www.ebi.ac.uk/pdbsum/3obq PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TS101_HUMAN TS101_HUMAN] Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses.<ref>PMID:11916981</ref> <ref>PMID:17853893</ref> <ref>PMID:17556548</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3obq" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Tumor susceptibility gene 101|Tumor susceptibility gene 101]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Hurley, J H]]
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[[Category: Large Structures]]
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[[Category: Im, Y J]]
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[[Category: Hurley JH]]
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[[Category: Protein transport]]
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[[Category: Im YJ]]
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[[Category: Protein transprot]]
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[[Category: Ubiquitin binding]]
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Current revision

Crystal Structure of the Tsg101 UEV domain in complex with a human HRS PSAP peptide

PDB ID 3obq

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