3p2m

<StructureSection load='3p2m' size='340' side='right' caption='[[3p2m]], [[Resolution|resolution]] 2.80&Aring;' scene=''>

<table><tr><td colspan='2'>[[3p2m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P2M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3P2M FirstGlance]. <br>

</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rv0045c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p2m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p2m RCSB], [http://www.ebi.ac.uk/pdbsum/3p2m PDBsum]</span></td></tr>

<div style="background-color:#fffaf0;">

== Publication Abstract from PubMed ==

There are at least 250 enzymes in Mycobacterium tuberculosis (M. tuberculosis) involved in lipid metabolism. Some of the enzymes are required for bacterial survival and full virulence. The esterase Rv0045c shares little amino acid sequence similarity with other members of the esterase/lipase family. Here, we report the 3D structure of Rv0045c. Our studies demonstrated that Rv0045c is a novel member of alpha/beta hydrolase fold family. The structure of esterase Rv0045c contains two distinct domains: the alpha/beta fold domain and the cap domain. The active site of esterase Rv0045c is highly conserved and comprised of two residues: Ser154 and His309. We proposed that Rv0045c probably employs two kinds of enzymatic mechanisms when hydrolyzing C-O ester bonds within substrates. The structure provides insight into the hydrolysis mechanism of the C-O ester bond, and will be helpful in understanding the ester/lipid metabolism in M. tuberculosis.

 

Crystal Structure of a Novel Esterase Rv0045c from Mycobacterium tuberculosis.,Zheng X, Guo J, Xu L, Li H, Zhang D, Zhang K, Sun F, Wen T, Liu S, Pang H PLoS One. 2011;6(5):e20506. Epub 2011 May 26. PMID:21637775<ref>PMID:21637775</ref>

 

<references/>

[[Category: Guo, J]]

[[Category: Li, H]]

[[Category: Liu, S]]

[[Category: Pang, H]]

[[Category: Sun, F]]

[[Category: Wen, T]]

[[Category: Xu, L]]

[[Category: Zhang, D]]

[[Category: Zhang, K]]

[[Category: Zheng, X D]]

[[Category: Hydrolase]]