3r8x
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==Crystal Structure of Methionyl-tRNA Formyltransferase from Yersinia pestis complexed with L-methionine== | ==Crystal Structure of Methionyl-tRNA Formyltransferase from Yersinia pestis complexed with L-methionine== | ||
| - | <StructureSection load='3r8x' size='340' side='right' caption='[[3r8x]], [[Resolution|resolution]] 2.26Å' scene=''> | + | <StructureSection load='3r8x' size='340' side='right'caption='[[3r8x]], [[Resolution|resolution]] 2.26Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3r8x]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3r8x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R8X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3R8X FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MET:METHIONINE'>MET</scene>, <scene name='pdbligand=MOE:METHOXY-ETHOXYL'>MOE</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.256Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MET:METHIONINE'>MET</scene>, <scene name='pdbligand=MOE:METHOXY-ETHOXYL'>MOE</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3r8x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r8x OCA], [https://pdbe.org/3r8x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3r8x RCSB], [https://www.ebi.ac.uk/pdbsum/3r8x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3r8x ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/FMT_YERPE FMT_YERPE] Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity). | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
[[Category: Yersinia pestis]] | [[Category: Yersinia pestis]] | ||
| - | [[Category: Anderson | + | [[Category: Anderson WF]] |
| - | + | [[Category: Hasseman J]] | |
| - | [[Category: Hasseman | + | [[Category: Joachimiak A]] |
| - | [[Category: Joachimiak | + | [[Category: Kim Y]] |
| - | [[Category: Kim | + | [[Category: Maltseva N]] |
| - | [[Category: Maltseva | + | |
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Current revision
Crystal Structure of Methionyl-tRNA Formyltransferase from Yersinia pestis complexed with L-methionine
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