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1qzt

From Proteopedia

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[[Image:1qzt.gif|left|200px]]
 
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{{Structure
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==Phosphotransacetylase from Methanosarcina thermophila==
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|PDB= 1qzt |SIZE=350|CAPTION= <scene name='initialview01'>1qzt</scene>, resolution 2.70&Aring;
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<StructureSection load='1qzt' size='340' side='right'caption='[[1qzt]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene>
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<table><tr><td colspan='2'>[[1qzt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanosarcina_thermophila Methanosarcina thermophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QZT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QZT FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Phosphate_acetyltransferase Phosphate acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.8 2.3.1.8]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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|GENE= PTA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2210 Methanosarcina thermophila])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qzt OCA], [https://pdbe.org/1qzt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qzt RCSB], [https://www.ebi.ac.uk/pdbsum/1qzt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qzt ProSAT]</span></td></tr>
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</table>
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'''Phosphotransacetylase from Methanosarcina thermophila'''
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== Function ==
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[https://www.uniprot.org/uniprot/PTAS_METTE PTAS_METTE]
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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Phosphotransacetylase (Pta) [EC 2.3.1.8] is ubiquitous in the carbon assimilation and energy-yielding pathways in anaerobic prokaryotes where it catalyzes the reversible transfer of the acetyl group from acetyl phosphate to CoA forming acetyl CoA and inorganic phosphate. The crystal structure of Pta from the methane-producing archaeon Methanosarcina thermophila, representing the first crystal structure of any Pta, was determined by multiwavelength anomalous diffraction at 2.7 A resolution. In solution and in the crystal, the enzyme forms a homodimer. Each monomer consists of two alpha/beta domains with a cleft along the domain boundary, which presumably contains the substrate binding sites. Comparison of the four monomers present in the asymmetric unit indicates substantial variations in the relative orientation of the two domains and the structure of the putative active site cleft. A search for structural homologs revealed the NADP(+)-dependent isocitrate and isopropylmalate dehydrogenases as the only homologs with a similar two-domain architecture.
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qz/1qzt_consurf.spt"</scriptWhenChecked>
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1QZT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanosarcina_thermophila Methanosarcina thermophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QZT OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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Crystal structure of phosphotransacetylase from the methanogenic archaeon Methanosarcina thermophila., Iyer PP, Lawrence SH, Luther KB, Rajashankar KR, Yennawar HP, Ferry JG, Schindelin H, Structure. 2004 Apr;12(4):559-67. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15062079 15062079]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qzt ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Methanosarcina thermophila]]
[[Category: Methanosarcina thermophila]]
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[[Category: Phosphate acetyltransferase]]
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[[Category: Ferry JG]]
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[[Category: Single protein]]
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[[Category: Iyer PP]]
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[[Category: Ferry, J G.]]
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[[Category: Lawrence SH]]
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[[Category: Iyer, P P.]]
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[[Category: Luther KB]]
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[[Category: Lawrence, S H.]]
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[[Category: Rajashankar KR]]
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[[Category: Luther, K B.]]
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[[Category: Schindelin H]]
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[[Category: Rajashankar, K R.]]
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[[Category: Yennawar HP]]
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[[Category: Schindelin, H.]]
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[[Category: Yennawar, H P.]]
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[[Category: SO4]]
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[[Category: acetate metabolism]]
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[[Category: acetyl coenzyme a (acetyl coa)]]
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[[Category: acetyl phosphate]]
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[[Category: coenzyme a (coa)]]
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[[Category: phosphotransacetylase (pta)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:44:53 2008''
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Current revision

Phosphotransacetylase from Methanosarcina thermophila

PDB ID 1qzt

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