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| - | ==Crystal Structure of Human Germline Antibody 3-23/B3==
| + | #REDIRECT [[5i1d]] This PDB entry is obsolete and replaced by 5i1d |
| - | <StructureSection load='3qos' size='340' side='right' caption='[[3qos]], [[Resolution|resolution]] 2.00Å' scene=''>
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| - | == Structural highlights ==
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| - | <table><tr><td colspan='2'>[[3qos]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QOS FirstGlance]. <br>
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| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qos OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qos RCSB], [http://www.ebi.ac.uk/pdbsum/3qos PDBsum]</span></td></tr>
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| - | </table>
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| - | <div style="background-color:#fffaf0;">
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| - | == Publication Abstract from PubMed ==
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| - | The human antibody repertoire is dominated by a few combinations of germline sequences, with the genes 3-23 for the heavy chain and B3 for the light chain being among the most frequently used. Despite this fact, there was no experimental structure of the antibody composed of 3-23 and B3. The crystal structure of the Fab fragment of the synthetic antibody composed of the 3-23 and B3 germline sequences was determined to provide a template for antibody modeling. The antigen-binding loops were found in the canonical conformations. Comparison to the other structures where either 3-23 or B3 is paired with a different chain reveals a significant deviation in the orientation of the variable domains.
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| - | Crystal structure of human germline antibody 3-23/B3.,Malia TJ, Obmolova G, Almagro JC, Gilliland GL, Teplyakov A Mol Immunol. 2011 Jul;48(12-13):1586-8. Epub 2011 May 24. PMID:21605907<ref>PMID:21605907</ref>
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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| - | </div>
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| - | == References ==
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| - | <references/>
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Homo sapiens]]
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| - | [[Category: Gilliland, G]]
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| - | [[Category: Malia, T]]
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| - | [[Category: Obmolova, G]]
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| - | [[Category: Teplyakov, A]]
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| - | [[Category: Immune system]]
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| - | [[Category: Immunoglobulin fold]]
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| - | [[Category: Monoclonal antibody]]
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