This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3rx2

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (17:20, 1 November 2023) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Crystal Structure of Human Aldose Reductase Complexed with Sulindac Sulfone==
==Crystal Structure of Human Aldose Reductase Complexed with Sulindac Sulfone==
-
<StructureSection load='3rx2' size='340' side='right' caption='[[3rx2]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
+
<StructureSection load='3rx2' size='340' side='right'caption='[[3rx2]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3rx2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RX2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RX2 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3rx2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RX2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RX2 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SLO:2-[(3Z)-6-FLUORANYL-2-METHYL-3-[(4-METHYLSULFONYLPHENYL)METHYLIDENE]INDEN-1-YL]ETHANOIC+ACID'>SLO</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3rx3|3rx3]], [[3rx4|3rx4]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SLO:2-[(3Z)-6-FLUORANYL-2-METHYL-3-[(4-METHYLSULFONYLPHENYL)METHYLIDENE]INDEN-1-YL]ETHANOIC+ACID'>SLO</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AKR1B1, ALDR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rx2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rx2 OCA], [https://pdbe.org/3rx2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rx2 RCSB], [https://www.ebi.ac.uk/pdbsum/3rx2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rx2 ProSAT]</span></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aldehyde_reductase Aldehyde reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.21 1.1.1.21] </span></td></tr>
+
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rx2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rx2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rx2 RCSB], [http://www.ebi.ac.uk/pdbsum/3rx2 PDBsum]</span></td></tr>
+
</table>
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 17: Line 18:
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
 +
<div class="pdbe-citations 3rx2" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
-
*[[Aldose Reductase|Aldose Reductase]]
+
*[[Aldose reductase 3D structures|Aldose reductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Aldehyde reductase]]
 
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Chen, J]]
+
[[Category: Large Structures]]
-
[[Category: Hu, X]]
+
[[Category: Chen J]]
-
[[Category: Luo, H]]
+
[[Category: Hu X]]
-
[[Category: Zheng, X]]
+
[[Category: Luo H]]
-
[[Category: Aldose reductase]]
+
[[Category: Zheng X]]
-
[[Category: Oxidoreductase]]
+

Current revision

Crystal Structure of Human Aldose Reductase Complexed with Sulindac Sulfone

PDB ID 3rx2

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3rx2"
Personal tools