3rzj

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==Duplex Interrogation by a Direct DNA Repair Protein in the Search of Damage==
==Duplex Interrogation by a Direct DNA Repair Protein in the Search of Damage==
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<StructureSection load='3rzj' size='340' side='right' caption='[[3rzj]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='3rzj' size='340' side='right'caption='[[3rzj]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3rzj]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RZJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RZJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3rzj]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RZJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RZJ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=XL3:PROPANE-1-THIOL'>XL3</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ME6:[(2R,3S,5R)-5-(4-AZANYL-3-METHYL-2-OXO-PYRIMIDIN-3-IUM-1-YL)-3-HYDROXY-OXOLAN-2-YL]METHYL+DIHYDROGEN+PHOSPHATE'>ME6</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=ME6:[(2R,3S,5R)-5-(4-AZANYL-3-METHYL-2-OXO-PYRIMIDIN-3-IUM-1-YL)-3-HYDROXY-OXOLAN-2-YL]METHYL+DIHYDROGEN+PHOSPHATE'>ME6</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=XL3:PROPANE-1-THIOL'>XL3</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3rzg|3rzg]], [[3rzh|3rzh]], [[3rzk|3rzk]], [[3rzl|3rzl]], [[3rzm|3rzm]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rzj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rzj OCA], [https://pdbe.org/3rzj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rzj RCSB], [https://www.ebi.ac.uk/pdbsum/3rzj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rzj ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ALKBH2, ABH2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rzj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rzj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rzj RCSB], [http://www.ebi.ac.uk/pdbsum/3rzj PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ALKB2_HUMAN ALKB2_HUMAN] Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron.<ref>PMID:12486230</ref> <ref>PMID:12594517</ref> <ref>PMID:16174769</ref> <ref>PMID:18519673</ref> <ref>PMID:18432238</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3rzj" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Dioxygenase|Dioxygenase]]
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*[[Dioxygenase 3D structures|Dioxygenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Chen, B]]
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[[Category: Large Structures]]
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[[Category: Dinner, A]]
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[[Category: Chen B]]
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[[Category: He, C]]
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[[Category: Dinner A]]
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[[Category: Jia, G]]
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[[Category: He C]]
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[[Category: Li, C]]
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[[Category: Jia G]]
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[[Category: Qi, B]]
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[[Category: Li C]]
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[[Category: Yang, C]]
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[[Category: Qi B]]
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[[Category: Yi, C]]
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[[Category: Yang C]]
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[[Category: Zhang, L]]
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[[Category: Yi C]]
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[[Category: Zhang, W]]
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[[Category: Zhang L]]
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[[Category: Demethylase]]
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[[Category: Zhang W]]
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[[Category: Jelly-roll]]
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[[Category: Nucleus]]
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[[Category: Oxidoreductase-dna complex]]
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[[Category: Protein-dna complex]]
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Current revision

Duplex Interrogation by a Direct DNA Repair Protein in the Search of Damage

PDB ID 3rzj

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