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1r5z

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[[Image:1r5z.jpg|left|200px]]
 
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{{Structure
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==Crystal Structure of Subunit C of V-ATPase==
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|PDB= 1r5z |SIZE=350|CAPTION= <scene name='initialview01'>1r5z</scene>, resolution 1.95&Aring;
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<StructureSection load='1r5z' size='340' side='right'caption='[[1r5z]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1r5z]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R5Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R5Z FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/H(+)-transporting_two-sector_ATPase H(+)-transporting two-sector ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.14 3.6.3.14]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r5z OCA], [https://pdbe.org/1r5z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r5z RCSB], [https://www.ebi.ac.uk/pdbsum/1r5z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r5z ProSAT]</span></td></tr>
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}}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/VATC_THET8 VATC_THET8] Produces ATP from ADP in the presence of a proton gradient across the membrane.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r5/1r5z_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r5z ConSurf].
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<div style="clear:both"></div>
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'''Crystal Structure of Subunit C of V-ATPase'''
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==See Also==
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*[[ATPase 3D structures|ATPase 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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The vacuole-type ATPases (V-ATPases) exist in various intracellular compartments of eukaryotic cells to regulate physiological processes by controlling the acidic environment. The crystal structure of the subunit C of Thermus thermophilus V-ATPase, homologous to eukaryotic subunit d of V-ATPases, has been determined at 1.95-A resolution and located into the holoenzyme complex structure obtained by single particle analysis as suggested by the results of subunit cross-linking experiments. The result shows that V-ATPase is substantially longer than the related F-type ATPase, due to the insertion of subunit C between the V(1) (soluble) and the V(o) (membrane bound) domains. Subunit C, attached to the V(o) domain, seems to have a socket like function in attaching the central-stalk subunits of the V(1) domain. This architecture seems essential for the reversible association/dissociation of the V(1) and the V(o) domains, unique for V-ATPase activity regulation.
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[[Category: Large Structures]]
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==About this Structure==
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1R5Z is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R5Z OCA].
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==Reference==
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Crystal structure of a central stalk subunit C and reversible association/dissociation of vacuole-type ATPase., Iwata M, Imamura H, Stambouli E, Ikeda C, Tamakoshi M, Nagata K, Makyio H, Hankamer B, Barber J, Yoshida M, Yokoyama K, Iwata S, Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):59-64. Epub 2003 Dec 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14684831 14684831]
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[[Category: H(+)-transporting two-sector ATPase]]
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[[Category: Single protein]]
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[[Category: Thermus thermophilus]]
[[Category: Thermus thermophilus]]
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[[Category: Barber, J.]]
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[[Category: Barber J]]
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[[Category: Hankamer, B.]]
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[[Category: Hankamer B]]
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[[Category: Ikeda, C.]]
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[[Category: Ikeda C]]
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[[Category: Imamura, H.]]
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[[Category: Imamura H]]
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[[Category: Iwata, M.]]
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[[Category: Iwata M]]
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[[Category: Iwata, S.]]
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[[Category: Iwata S]]
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[[Category: Makyio, H.]]
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[[Category: Makyio H]]
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[[Category: Nagata, K.]]
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[[Category: Nagata K]]
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[[Category: Stambouli, E.]]
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[[Category: Stambouli E]]
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[[Category: Tamakoshi, M.]]
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[[Category: Tamakoshi M]]
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[[Category: Yokoyama, K.]]
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[[Category: Yokoyama K]]
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[[Category: Yoshida, M.]]
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[[Category: Yoshida M]]
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[[Category: alpha-helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:47:18 2008''
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Current revision

Crystal Structure of Subunit C of V-ATPase

PDB ID 1r5z

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