3w0g

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==Crystal Structure of Rat VDR Ligand Binding Domain in Complex with Novel Nonsecosteroidal Ligands==
==Crystal Structure of Rat VDR Ligand Binding Domain in Complex with Novel Nonsecosteroidal Ligands==
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<StructureSection load='3w0g' size='340' side='right' caption='[[3w0g]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
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<StructureSection load='3w0g' size='340' side='right'caption='[[3w0g]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3w0g]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W0G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3W0G FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3w0g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W0G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W0G FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=W07:(2S)-3-{4-[2-(4-{[(2R)-2-HYDROXY-3,3-DIMETHYLBUTYL]OXY}PHENYL)PROPAN-2-YL]PHENOXY}PROPANE-1,2-DIOL'>W07</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.94&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3w0h|3w0h]], [[3w0i|3w0i]], [[3w0j|3w0j]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=W07:(2S)-3-{4-[2-(4-{[(2R)-2-HYDROXY-3,3-DIMETHYLBUTYL]OXY}PHENYL)PROPAN-2-YL]PHENOXY}PROPANE-1,2-DIOL'>W07</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Nr1i1, Vdr ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w0g OCA], [https://pdbe.org/3w0g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w0g RCSB], [https://www.ebi.ac.uk/pdbsum/3w0g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w0g ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3w0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w0g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3w0g RCSB], [http://www.ebi.ac.uk/pdbsum/3w0g PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/VDR_RAT VDR_RAT] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.<ref>PMID:17227670</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3w0g" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Vitamin D receptor|Vitamin D receptor]]
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*[[Vitamin D receptor 3D structures|Vitamin D receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Asano, L]]
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[[Category: Asano L]]
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[[Category: Ito, I]]
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[[Category: Ito I]]
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[[Category: Kuwabara, N]]
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[[Category: Kuwabara N]]
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[[Category: Miyachi, H]]
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[[Category: Miyachi H]]
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[[Category: Shimizu, T]]
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[[Category: Shimizu T]]
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[[Category: Waku, T]]
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[[Category: Waku T]]
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[[Category: Yanagisawa, J]]
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[[Category: Yanagisawa J]]
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[[Category: Gene regulation]]
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[[Category: Transcription]]
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Current revision

Crystal Structure of Rat VDR Ligand Binding Domain in Complex with Novel Nonsecosteroidal Ligands

PDB ID 3w0g

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