This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1r8o

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:10, 17 April 2024) (edit) (undo)
 
(13 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1r8o.jpg|left|200px]]
 
-
{{Structure
+
==Crystal structure of an unusual Kunitz-type trypsin inhibitor from Copaifera langsdorffii seeds==
-
|PDB= 1r8o |SIZE=350|CAPTION= <scene name='initialview01'>1r8o</scene>, resolution 1.83&Aring;
+
<StructureSection load='1r8o' size='340' side='right'caption='[[1r8o]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND=
+
<table><tr><td colspan='2'>[[1r8o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Copaifera_langsdorffii Copaifera langsdorffii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R8O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R8O FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.83&#8491;</td></tr>
-
|GENE=
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r8o OCA], [https://pdbe.org/1r8o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r8o RCSB], [https://www.ebi.ac.uk/pdbsum/1r8o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r8o ProSAT]</span></td></tr>
-
}}
+
</table>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r8/1r8o_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r8o ConSurf].
 +
<div style="clear:both"></div>
-
'''Crystal structure of an unusual Kunitz-type trypsin inhibitor from Copaifera langsdorffii seeds'''
+
==See Also==
-
 
+
*[[Trypsin inhibitor 3D structures|Trypsin inhibitor 3D structures]]
-
 
+
__TOC__
-
==Overview==
+
</StructureSection>
-
The crystallographic structure of a novel trypsin inhibitor (CTI) from Copaifera langsdorffii is reported. The structure was solved by MIRAS procedure and refined to a crystallographic residual of 17.3% (R(free) = 20.3%) at 1.8 A resolution. Two isomorphous derivatives were obtained by quick cryo-soaking approach. CTI is the first structure of a member of Kunitz (STI) family formed by two noncovalently bound polypeptide chains and only one disulfide bridge. A standard Kunitz-type inhibitor has a single polypeptide chain and two disulfide bridges. Structural features granting CTI high inhibitory activity are discussed.
+
-
 
+
-
==About this Structure==
+
-
1R8O is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Copaifera_langsdorffii Copaifera langsdorffii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R8O OCA].
+
-
 
+
-
==Reference==
+
-
Three-dimensional structure of an unusual Kunitz (STI) type trypsin inhibitor from Copaifera langsdorffii., Krauchenco S, Nagem RA, da Silva JA, Marangoni S, Polikarpov I, Biochimie. 2004 Mar;86(3):167-72. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15134830 15134830]
+
[[Category: Copaifera langsdorffii]]
[[Category: Copaifera langsdorffii]]
-
[[Category: Protein complex]]
+
[[Category: Large Structures]]
-
[[Category: Krauchenco, S.]]
+
[[Category: Krauchenco S]]
-
[[Category: Marangoni, S.]]
+
[[Category: Marangoni S]]
-
[[Category: Nagem, R A.P.]]
+
[[Category: Nagem RAP]]
-
[[Category: Polikarpov, I.]]
+
[[Category: Polikarpov I]]
-
[[Category: Silva, J A.da.]]
+
[[Category: Da Silva JA]]
-
[[Category: beta-trefoil fold]]
+
-
[[Category: copaifera langsdorffii]]
+
-
[[Category: kunitz (sti) trypsin inhibitor]]
+
-
[[Category: x-ray structure]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:48:21 2008''
+

Current revision

Crystal structure of an unusual Kunitz-type trypsin inhibitor from Copaifera langsdorffii seeds

PDB ID 1r8o

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1r8o"
Personal tools