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3v3q

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==Crystal Structure of Human Nur77 Ligand-binding Domain in Complex with Ethyl 2-[2,3,4 trimethoxy-6(1-octanoyl)phenyl]acetate==
==Crystal Structure of Human Nur77 Ligand-binding Domain in Complex with Ethyl 2-[2,3,4 trimethoxy-6(1-octanoyl)phenyl]acetate==
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<StructureSection load='3v3q' size='340' side='right' caption='[[3v3q]], [[Resolution|resolution]] 2.22&Aring;' scene=''>
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<StructureSection load='3v3q' size='340' side='right'caption='[[3v3q]], [[Resolution|resolution]] 2.22&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3v3q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V3Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V3Q FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3v3q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V3Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V3Q FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TMY:ETHYL+(2,3,4-TRIMETHOXY-6-OCTANOYLPHENYL)ACETATE'>TMY</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.22&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3v3e|3v3e]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TMY:ETHYL+(2,3,4-TRIMETHOXY-6-OCTANOYLPHENYL)ACETATE'>TMY</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NR4A1, GFRP1, HMR, NAK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v3q OCA], [https://pdbe.org/3v3q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v3q RCSB], [https://www.ebi.ac.uk/pdbsum/3v3q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v3q ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v3q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v3q RCSB], [http://www.ebi.ac.uk/pdbsum/3v3q PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NR4A1_HUMAN NR4A1_HUMAN] Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2.<ref>PMID:15466594</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3v3q" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Chen, Y]]
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[[Category: Large Structures]]
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[[Category: Lin, T]]
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[[Category: Chen Y]]
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[[Category: Shi, C]]
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[[Category: Lin T]]
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[[Category: Wu, Q]]
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[[Category: Shi C]]
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[[Category: Yang, K]]
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[[Category: Wu Q]]
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[[Category: Zhan, Y]]
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[[Category: Yang K]]
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[[Category: Zhang, Q]]
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[[Category: Zhan Y]]
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[[Category: Orphan nuclear receptor]]
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[[Category: Zhang Q]]
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[[Category: Protein-antagonist complex]]
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[[Category: Transcription]]
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[[Category: Transcription-antagonist complex]]
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Current revision

Crystal Structure of Human Nur77 Ligand-binding Domain in Complex with Ethyl 2-[2,3,4 trimethoxy-6(1-octanoyl)phenyl]acetate

PDB ID 3v3q

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