4c3j

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==Structure of 14-subunit RNA polymerase I at 3.35 A resolution, crystal form C2-90==
==Structure of 14-subunit RNA polymerase I at 3.35 A resolution, crystal form C2-90==
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<StructureSection load='4c3j' size='340' side='right' caption='[[4c3j]], [[Resolution|resolution]] 3.35&Aring;' scene=''>
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<StructureSection load='4c3j' size='340' side='right'caption='[[4c3j]], [[Resolution|resolution]] 3.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4c3j]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C3J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C3J FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4c3j]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C3J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C3J FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.35&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4c3h|4c3h]], [[4c3i|4c3i]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_RNA_polymerase DNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.6 2.7.7.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c3j OCA], [https://pdbe.org/4c3j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c3j RCSB], [https://www.ebi.ac.uk/pdbsum/4c3j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c3j ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c3j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c3j RCSB], [http://www.ebi.ac.uk/pdbsum/4c3j PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RPA1_YEAST RPA1_YEAST] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4c3j" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[RNA polymerase|RNA polymerase]]
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== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: DNA-directed RNA polymerase]]
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Fernandez-Tornero, C]]
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[[Category: Fernandez-Tornero C]]
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[[Category: Gruene, T]]
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[[Category: Gruene T]]
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[[Category: Legrand, P]]
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[[Category: Legrand P]]
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[[Category: Moreno-Morcillo, M]]
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[[Category: Moreno-Morcillo M]]
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[[Category: Muller, C W]]
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[[Category: Muller CW]]
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[[Category: Rashid, U J]]
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[[Category: Rashid UJ]]
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[[Category: Ruiz, F M]]
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[[Category: Ruiz FM]]
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[[Category: Steuerwald, U]]
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[[Category: Steuerwald U]]
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[[Category: Taylor, N M.I]]
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[[Category: Taylor NMI]]
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[[Category: Transcription]]
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Current revision

Structure of 14-subunit RNA polymerase I at 3.35 A resolution, crystal form C2-90

PDB ID 4c3j

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