4bik

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==Structure of a disulfide locked mutant of Intermedilysin with human CD59==
==Structure of a disulfide locked mutant of Intermedilysin with human CD59==
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<StructureSection load='4bik' size='340' side='right' caption='[[4bik]], [[Resolution|resolution]] 3.49&Aring;' scene=''>
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<StructureSection load='4bik' size='340' side='right'caption='[[4bik]], [[Resolution|resolution]] 3.49&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4bik]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Streptococcus_intermedius Streptococcus intermedius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BIK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BIK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4bik]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Streptococcus_intermedius Streptococcus intermedius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BIK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BIK FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bik OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bik RCSB], [http://www.ebi.ac.uk/pdbsum/4bik PDBsum]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.494&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bik OCA], [https://pdbe.org/4bik PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bik RCSB], [https://www.ebi.ac.uk/pdbsum/4bik PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bik ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
 
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[[http://www.uniprot.org/uniprot/CD59_HUMAN CD59_HUMAN]] Defects in CD59 are the cause of CD59 deficiency (CD59D) [MIM:[http://omim.org/entry/612300 612300]].<ref>PMID:1382994</ref>
 
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CD59_HUMAN CD59_HUMAN]] Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes.
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[https://www.uniprot.org/uniprot/Q9LCB8_STRIT Q9LCB8_STRIT]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4bik" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
*[[CD59|CD59]]
*[[CD59|CD59]]
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*[[Cytolysin 3D structures|Cytolysin 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Large Structures]]
[[Category: Streptococcus intermedius]]
[[Category: Streptococcus intermedius]]
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[[Category: Brooks, N J]]
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[[Category: Brooks NJ]]
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[[Category: Bubeck, D]]
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[[Category: Bubeck D]]
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[[Category: Johnson, S]]
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[[Category: Johnson S]]
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[[Category: Lea, S M]]
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[[Category: Lea SM]]
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[[Category: Smith, R A.G]]
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[[Category: Smith RAG]]
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[[Category: Cholesterol dependent cytotoxin]]
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[[Category: Complement]]
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[[Category: Immune system]]
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[[Category: Membrane attack complex]]
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Current revision

Structure of a disulfide locked mutant of Intermedilysin with human CD59

PDB ID 4bik

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