4bmk

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==Serine Palmitoyltransferase K265A from S. paucimobilis with bound PLP- Myriocin Aldimine==
==Serine Palmitoyltransferase K265A from S. paucimobilis with bound PLP- Myriocin Aldimine==
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<StructureSection load='4bmk' size='340' side='right' caption='[[4bmk]], [[Resolution|resolution]] 1.62&Aring;' scene=''>
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<StructureSection load='4bmk' size='340' side='right'caption='[[4bmk]], [[Resolution|resolution]] 1.62&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4bmk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sphingomonas_paucimobilis Sphingomonas paucimobilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BMK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BMK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4bmk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sphingomonas_paucimobilis Sphingomonas paucimobilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BMK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BMK FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MYB:DECARBOXYLATED+MYRIOCIN'>MYB</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.62&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Serine_C-palmitoyltransferase Serine C-palmitoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.50 2.3.1.50] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MYB:DECARBOXYLATED+MYRIOCIN'>MYB</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bmk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bmk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bmk RCSB], [http://www.ebi.ac.uk/pdbsum/4bmk PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bmk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bmk OCA], [https://pdbe.org/4bmk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bmk RCSB], [https://www.ebi.ac.uk/pdbsum/4bmk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bmk ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SPT_SPHPI SPT_SPHPI] Catalyzes the condensation of L-serine with palmitoyl-CoA (hexadecanoyl-CoA) to produce 3-oxosphinganine (PubMed:11279212, PubMed:17557831, PubMed:17559874, PubMed:19376777). Exhibits a broad substrate specificity concerning the chain length and the degree of unsaturation of acyl-CoA (PubMed:11279212, PubMed:19376777).<ref>PMID:11279212</ref> <ref>PMID:17557831</ref> <ref>PMID:17559874</ref> <ref>PMID:19376777</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4bmk" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Serine palmitoyltransferase|Serine palmitoyltransferase]]
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*[[Serine palmitoyltransferase 3D structures|Serine palmitoyltransferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Serine C-palmitoyltransferase]]
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[[Category: Large Structures]]
[[Category: Sphingomonas paucimobilis]]
[[Category: Sphingomonas paucimobilis]]
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[[Category: Beattie, A E]]
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[[Category: Beattie AE]]
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[[Category: Campopiano, D J]]
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[[Category: Campopiano DJ]]
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[[Category: Clarke, D J]]
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[[Category: Clarke DJ]]
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[[Category: Dunn, T M]]
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[[Category: Dunn TM]]
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[[Category: Lowther, J]]
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[[Category: Lowther J]]
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[[Category: McMahon, S A]]
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[[Category: McMahon SA]]
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[[Category: Naismith, J H]]
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[[Category: Naismith JH]]
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[[Category: Wadsworth, J M]]
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[[Category: Wadsworth JM]]
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[[Category: Antibiotic isp-1]]
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[[Category: External aldimine]]
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[[Category: Inhibitor]]
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[[Category: Natural product]]
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[[Category: Sphingolipid]]
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[[Category: Transferase]]
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[[Category: Transferase-antibiotic complex]]
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Current revision

Serine Palmitoyltransferase K265A from S. paucimobilis with bound PLP- Myriocin Aldimine

PDB ID 4bmk

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