4efe

<StructureSection load='4efe' size='340' side='right'caption='[[4efe]], [[Resolution|resolution]] 2.00&Aring;' scene=''>

<table><tr><td colspan='2'>[[4efe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EFE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EFE FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0OV:[4-AMINO-2-{[(1S,2R)-2-METHYLCYCLOHEXYL]OXY}-5-OXOPYRIDO[2,3-D]PYRIMIDIN-8(5H)-YL]ACETONITRILE'>0OV</scene>, <scene name='pdbligand=NMN:BETA-NICOTINAMIDE+RIBOSE+MONOPHOSPHATE'>NMN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4efe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4efe OCA], [https://pdbe.org/4efe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4efe RCSB], [https://www.ebi.ac.uk/pdbsum/4efe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4efe ProSAT]</span></td></tr>

== Function ==

[https://www.uniprot.org/uniprot/DNLJ_ENTFA DNLJ_ENTFA] DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity).

*[[DNA ligase 3D structures|DNA ligase 3D structures]]

[[Category: Charifson P]]

[[Category: Wang T]]

[[Category: Wei Y]]

[[Category: Xu W]]