1ruw

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[[Image:1ruw.gif|left|200px]]
 
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{{Structure
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==Crystal structure of the SH3 domain from S. cerevisiae Myo3==
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|PDB= 1ruw |SIZE=350|CAPTION= <scene name='initialview01'>1ruw</scene>, resolution 1.80&Aring;
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<StructureSection load='1ruw' size='340' side='right'caption='[[1ruw]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>
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<table><tr><td colspan='2'>[[1ruw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RUW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RUW FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ruw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ruw OCA], [https://pdbe.org/1ruw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ruw RCSB], [https://www.ebi.ac.uk/pdbsum/1ruw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ruw ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MYO3_YEAST MYO3_YEAST] One of two redundant type-I myosins implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization and for the internalization step in endocytosis. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions redundantly with LAS17 as actin nucleation-promoting factor (NPF) for the Arp2/3 complex. Motor domain phosphorylation by PAK kinases CLA4 and STE20 promotes CDC42-regulated actin assembly. Functions together with the NPF PAN1 in late stages of endocytosis. Motor domain phosphorylation by PDK1 kinases PKH1 and PKH2, and by SGK kinases YPK1 and YPK2, promotes ligand-induced, but not constitutive endocytosis of the G protein-coupled receptor STE2.<ref>PMID:8682864</ref> <ref>PMID:8614799</ref> <ref>PMID:9388196</ref> <ref>PMID:10648568</ref> <ref>PMID:10648569</ref> <ref>PMID:12725728</ref> <ref>PMID:12808026</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ru/1ruw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ruw ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of the SH3 domain from S. cerevisiae Myo3'''
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==See Also==
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*[[Myosin 3D Structures|Myosin 3D Structures]]
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== References ==
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==About this Structure==
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<references/>
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1RUW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RUW OCA].
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Single protein]]
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[[Category: Kursula I]]
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[[Category: Kursula, I.]]
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[[Category: Kursula P]]
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[[Category: Kursula, P.]]
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[[Category: Lehmann F]]
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[[Category: Lehmann, F.]]
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[[Category: Song YH]]
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[[Category: Song, Y H.]]
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[[Category: Wilmanns M]]
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[[Category: Wilmanns, M.]]
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[[Category: IMD]]
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[[Category: high-throughput]]
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[[Category: myo3]]
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[[Category: sh3 domain]]
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[[Category: structural genomic]]
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[[Category: yeast]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:56:32 2008''
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Current revision

Crystal structure of the SH3 domain from S. cerevisiae Myo3

PDB ID 1ruw

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