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1rxt

From Proteopedia

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[[Image:1rxt.gif|left|200px]]
 
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{{Structure
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==Crystal structure of human myristoyl-CoA:protein N-myristoyltransferase.==
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|PDB= 1rxt |SIZE=350|CAPTION= <scene name='initialview01'>1rxt</scene>, resolution 3.0&Aring;
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<StructureSection load='1rxt' size='340' side='right'caption='[[1rxt]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene> and <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene>
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<table><tr><td colspan='2'>[[1rxt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RXT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RXT FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rxt OCA], [https://pdbe.org/1rxt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rxt RCSB], [https://www.ebi.ac.uk/pdbsum/1rxt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rxt ProSAT]</span></td></tr>
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</table>
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'''Crystal structure of human myristoyl-CoA:protein N-myristoyltransferase.'''
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== Function ==
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[https://www.uniprot.org/uniprot/NMT1_HUMAN NMT1_HUMAN] Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.
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== Evolutionary Conservation ==
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==Disease==
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[[Image:Consurf_key_small.gif|200px|right]]
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Known disease associated with this structure: Thyroid carcinoma, nonmedullary OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=606240 606240]]
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rx/1rxt_consurf.spt"</scriptWhenChecked>
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1RXT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RXT OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Glycylpeptide N-tetradecanoyltransferase]]
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rxt ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Abeles, R H.]]
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[[Category: Abeles RH]]
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[[Category: Frey, G.]]
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[[Category: Frey G]]
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[[Category: Petsko, G A.]]
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[[Category: Petsko GA]]
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[[Category: Ringe, D.]]
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[[Category: Ringe D]]
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[[Category: Wang, Y.]]
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[[Category: Wang Y]]
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[[Category: Yang, J.]]
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[[Category: Yang J]]
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[[Category: CO]]
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[[Category: SO4]]
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[[Category: alpha-beta structure; unique n-myristoyltransferase fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:57:39 2008''
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Current revision

Crystal structure of human myristoyl-CoA:protein N-myristoyltransferase.

PDB ID 1rxt

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