4fkw

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==Crystal structure of the cdk2 in complex with oxindole inhibitor==
==Crystal structure of the cdk2 in complex with oxindole inhibitor==
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<StructureSection load='4fkw' size='340' side='right' caption='[[4fkw]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='4fkw' size='340' side='right'caption='[[4fkw]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4fkw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FKW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FKW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4fkw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FKW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FKW FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=62K:2-METHYLPROPYL+(3Z)-2-OXO-3-[2-(4-SULFAMOYLPHENYL)HYDRAZINYLIDENE]-2,3-DIHYDRO-1H-INDOLE-5-CARBOXYLATE'>62K</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=62K:2-METHYLPROPYL+(3Z)-2-OXO-3-[2-(4-SULFAMOYLPHENYL)HYDRAZINYLIDENE]-2,3-DIHYDRO-1H-INDOLE-5-CARBOXYLATE'>62K</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ek3|4ek3]], [[4ek4|4ek4]], [[4ek5|4ek5]], [[4ek6|4ek6]], [[4ek8|4ek8]], [[4fkg|4fkg]], [[4fki|4fki]], [[4fkj|4fkj]], [[4fkl|4fkl]], [[4fko|4fko]], [[4fkp|4fkp]], [[4fkq|4fkq]], [[4fkr|4fkr]], [[4fks|4fks]], [[4fkt|4fkt]], [[4fku|4fku]], [[4fkv|4fkv]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fkw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fkw OCA], [https://pdbe.org/4fkw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fkw RCSB], [https://www.ebi.ac.uk/pdbsum/4fkw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fkw ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CDK2, CDKN2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fkw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fkw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fkw RCSB], [http://www.ebi.ac.uk/pdbsum/4fkw PDBsum]</span></td></tr>
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</table>
</table>
==See Also==
==See Also==
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*[[Cell division protein kinase 2|Cell division protein kinase 2]]
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*[[Cyclin-dependent kinase 3D structures|Cyclin-dependent kinase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cyclin-dependent kinase]]
 
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Kang, Y N]]
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[[Category: Large Structures]]
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[[Category: Stuckey, J A]]
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[[Category: Kang YN]]
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[[Category: Transferase]]
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[[Category: Stuckey JA]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Crystal structure of the cdk2 in complex with oxindole inhibitor

PDB ID 4fkw

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