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4f9o
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==Crystal Structure of recombinant human Hexokinase type I with 2-deoxy-Glucose 6-Phosphate== | ==Crystal Structure of recombinant human Hexokinase type I with 2-deoxy-Glucose 6-Phosphate== | ||
| - | <StructureSection load='4f9o' size='340' side='right' caption='[[4f9o]], [[Resolution|resolution]] 2.65Å' scene=''> | + | <StructureSection load='4f9o' size='340' side='right'caption='[[4f9o]], [[Resolution|resolution]] 2.65Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4f9o]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4f9o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F9O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F9O FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0NZ:2-DEOXY-6-O-PHOSPHONO-BETA-D-ARABINO-HEXOPYRANOSE'>0NZ</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0NZ:2-DEOXY-6-O-PHOSPHONO-BETA-D-ARABINO-HEXOPYRANOSE'>0NZ</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f9o OCA], [https://pdbe.org/4f9o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f9o RCSB], [https://www.ebi.ac.uk/pdbsum/4f9o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f9o ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/HXK1_HUMAN HXK1_HUMAN] Defects in HK1 are the cause of hexokinase deficiency (HK deficiency) [MIM:[https://omim.org/entry/235700 235700]. HK deficiency is a rare autosomal recessive disease with nonspherocytic hemolytic anemia as the predominant clinical feature. |
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/HXK1_HUMAN HXK1_HUMAN] | |
==See Also== | ==See Also== | ||
| - | *[[Hexokinase|Hexokinase]] | + | *[[Hexokinase 3D structures|Hexokinase 3D structures]] |
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Hexokinase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Honzatko RB]] |
| - | [[Category: | + | [[Category: Shen L]] |
| - | + | ||
Current revision
Crystal Structure of recombinant human Hexokinase type I with 2-deoxy-Glucose 6-Phosphate
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