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4hqx
From Proteopedia
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==CRYSTAL STRUCTURE OF HUMAN PDGF-BB IN COMPLEX WITH A Modified nucleotide aptamer (SOMAmer SL4)== | ==CRYSTAL STRUCTURE OF HUMAN PDGF-BB IN COMPLEX WITH A Modified nucleotide aptamer (SOMAmer SL4)== | ||
| - | <StructureSection load='4hqx' size='340' side='right' caption='[[4hqx]], [[Resolution|resolution]] 2.30Å' scene=''> | + | <StructureSection load='4hqx' size='340' side='right'caption='[[4hqx]], [[Resolution|resolution]] 2.30Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4hqx]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4hqx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HQX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HQX FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=18M:2-O-METHYLGUANOSINE+3,5-BIS(DIHYDROGEN+PHOSPHATE)'>18M</scene>, <scene name='pdbligand=18Q:2-DEOXY-5-[(THIOPHEN-2-YLMETHYL)CARBAMOYL]URIDINE+5-(DIHYDROGEN+PHOSPHATE)'>18Q</scene>, <scene name='pdbligand=A2M:2-O-METHYLADENOSINE+5-(DIHYDROGEN+PHOSPHATE)'>A2M</scene>, <scene name='pdbligand=DUZ:5-(BENZYLCARBAMOYL)-2-DEOXYURIDINE+5-(DIHYDROGEN+PHOSPHATE)'>DUZ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PE6:PHOSPHORYL-HEXAETHYLENE+GLYCOL'>PE6</scene>, <scene name='pdbligand=UBI:2-DEOXY-5-[(2-METHYLPROPYL)CARBAMOYL]URIDINE+5-(DIHYDROGEN+PHOSPHATE)'>UBI</scene>, <scene name='pdbligand=UPE:2-DEOXY-5-[(2-PHENYLETHYL)CARBAMOYL]URIDINE+5-(DIHYDROGEN+PHOSPHATE)'>UPE</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hqx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hqx OCA], [https://pdbe.org/4hqx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hqx RCSB], [https://www.ebi.ac.uk/pdbsum/4hqx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hqx ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/PDGFB_HUMAN PDGFB_HUMAN] Note=A chromosomal aberration involving PDGFB is found in dermatofibrosarcoma protuberans. Translocation t(17;22)(q22;q13) with PDGFB.<ref>PMID:12660034</ref> |
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/PDGFB_HUMAN PDGFB_HUMAN] Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity). |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 4hqx" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Davies | + | [[Category: Large Structures]] |
| - | [[Category: Edwards | + | [[Category: Davies DR]] |
| - | [[Category: Gelinas | + | [[Category: Edwards TE]] |
| - | [[Category: Janjic | + | [[Category: Gelinas AD]] |
| - | [[Category: Jarvis | + | [[Category: Janjic N]] |
| - | [[Category: Zhang | + | [[Category: Jarvis TC]] |
| - | + | [[Category: Zhang C]] | |
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Current revision
CRYSTAL STRUCTURE OF HUMAN PDGF-BB IN COMPLEX WITH A Modified nucleotide aptamer (SOMAmer SL4)
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Categories: Homo sapiens | Large Structures | Davies DR | Edwards TE | Gelinas AD | Janjic N | Jarvis TC | Zhang C
