4huh

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==Structure of the bacteriophage T4 tail terminator protein, gp15 (C-terminal truncation mutant 1-261).==
==Structure of the bacteriophage T4 tail terminator protein, gp15 (C-terminal truncation mutant 1-261).==
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<StructureSection load='4huh' size='340' side='right' caption='[[4huh]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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<StructureSection load='4huh' size='340' side='right'caption='[[4huh]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4huh]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HUH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HUH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4huh]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HUH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HUH FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4hud|4hud]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10665 Enterobacteria phage T4])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4huh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4huh OCA], [https://pdbe.org/4huh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4huh RCSB], [https://www.ebi.ac.uk/pdbsum/4huh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4huh ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4huh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4huh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4huh RCSB], [http://www.ebi.ac.uk/pdbsum/4huh PDBsum]</span></td></tr>
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</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/COMPL_BPT4 COMPL_BPT4] Stabilizes the tail sheath structure and acts as a connector between the end of tail and the portal vertex of the capsid.<ref>PMID:23434847</ref>
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A hexamer of the bacteriophage T4 tail terminator protein, gp15, attaches to the top of the phage tail stabilizing the contractile sheath and forming the interface for binding of the independently assembled head. Here we report the crystal structure of the gp15 hexamer, describe its interactions in T4 virions that have either an extended tail or a contracted tail, and discuss its structural relationship to other phage proteins. The neck of T4 virions is decorated by the "collar" and "whiskers", made of fibritin molecules. Fibritin acts as a chaperone helping to attach the long tail fibers to the virus during the assembly process. The collar and whiskers are environment-sensing devices, regulating the retraction of the long tail fibers under unfavorable conditions, thus preventing infection. Cryo-electron microscopy analysis suggests that twelve fibritin molecules attach to the phage neck with six molecules forming the collar and six molecules forming the whiskers.
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The Molecular Architecture of the Bacteriophage T4 Neck.,Fokine A, Zhang Z, Kanamaru S, Bowman VD, Aksyuk AA, Arisaka F, Rao VB, Rossmann MG J Mol Biol. 2013 Feb 19. pii: S0022-2836(13)00098-3. doi:, 10.1016/j.jmb.2013.02.012. PMID:23434847<ref>PMID:23434847</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Enterobacteria phage t4]]
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[[Category: Escherichia virus T4]]
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[[Category: Aksyuk, A]]
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[[Category: Large Structures]]
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[[Category: Arisaka, F]]
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[[Category: Aksyuk A]]
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[[Category: Bowman, V D]]
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[[Category: Arisaka F]]
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[[Category: Fokine, A]]
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[[Category: Bowman VD]]
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[[Category: Kanamaru, S]]
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[[Category: Fokine A]]
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[[Category: Rao, V B]]
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[[Category: Kanamaru S]]
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[[Category: Rossmann, M G]]
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[[Category: Rao VB]]
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[[Category: Zhang, Z]]
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[[Category: Rossmann MG]]
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[[Category: Viral protein]]
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[[Category: Zhang Z]]

Current revision

Structure of the bacteriophage T4 tail terminator protein, gp15 (C-terminal truncation mutant 1-261).

PDB ID 4huh

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