1s5i

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[[Image:1s5i.jpg|left|200px]]
 
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{{Structure
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==Fab (LNKB-2) of monoclonal antibody to Human Interleukin-2, crystal structure==
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|PDB= 1s5i |SIZE=350|CAPTION= <scene name='initialview01'>1s5i</scene>, resolution 2.7&Aring;
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<StructureSection load='1s5i' size='340' side='right'caption='[[1s5i]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1s5i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S5I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S5I FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s5i OCA], [https://pdbe.org/1s5i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s5i RCSB], [https://www.ebi.ac.uk/pdbsum/1s5i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s5i ProSAT]</span></td></tr>
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}}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IGH1M_MOUSE IGH1M_MOUSE]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s5/1s5i_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s5i ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The three-dimensional structure of the antigen-binding fragment of a monoclonal antibody to human interleukin-2 in a new crystal form (space group P2(1)2(1)2(1); unit cell parameters: a = 42.82, b = 90.68, and c = 139.82 A) was determined by the X-ray molecular replacement method at the resolution of 2.7 A. The protein folding and the stereochemistry of its antigen-binding site were comparatively analyzed. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2004, vol. 30, no. 5; see also http: // www.maik.ru.
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'''Fab (LNKB-2) of monoclonal antibody to Human Interleukin-2, crystal structure'''
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[A new crystal form of the Fab fragment of a monoclonal antibody to human interleukin-2: the three-dimensional structure at 2.7 A resolution].,Pletnev VZ, Goriacheva EA, Tsygannik IN, Nesmeianov VA, Pletnev SV, Pangborn W, Daux W Bioorg Khim. 2004 Sep-Oct;30(5):466-9. PMID:15562966<ref>PMID:15562966</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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1S5I is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S5I OCA].
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<div class="pdbe-citations 1s5i" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Duax W]]
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[[Category: Duax, W.]]
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[[Category: Goryacheva EA]]
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[[Category: Goryacheva, E A.]]
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[[Category: Nesmeyanov VA]]
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[[Category: Nesmeyanov, V A.]]
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[[Category: Pangborn W]]
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[[Category: Pangborn, W.]]
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[[Category: Pletnev SV]]
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[[Category: Pletnev, S V.]]
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[[Category: Pletnev VZ]]
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[[Category: Pletnev, V Z.]]
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[[Category: Tsygannik IN]]
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[[Category: Tsygannik, I N.]]
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[[Category: antigen-binding fragment]]
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[[Category: crystal structure]]
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[[Category: interleukin-2]]
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[[Category: monoclonal antibody]]
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[[Category: x-ray analysis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:00:45 2008''
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Current revision

Fab (LNKB-2) of monoclonal antibody to Human Interleukin-2, crystal structure

PDB ID 1s5i

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