4jgh

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==Structure of the SOCS2-Elongin BC complex bound to an N-terminal fragment of Cullin5==
==Structure of the SOCS2-Elongin BC complex bound to an N-terminal fragment of Cullin5==
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<StructureSection load='4jgh' size='340' side='right' caption='[[4jgh]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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<StructureSection load='4jgh' size='340' side='right'caption='[[4jgh]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4jgh]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JGH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JGH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4jgh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JGH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JGH FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CIS2, Homo sapiens, SOCS2, SSI2, STATI2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), Mus musculus, Tceb2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), Mus musculus, Tceb1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), CUL5, Homo sapiens, VACM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jgh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jgh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jgh RCSB], [http://www.ebi.ac.uk/pdbsum/4jgh PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jgh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jgh OCA], [https://pdbe.org/4jgh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jgh RCSB], [https://www.ebi.ac.uk/pdbsum/4jgh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jgh ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SOCS2_HUMAN SOCS2_HUMAN] SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4jgh" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Transcription factor SIII|Transcription factor SIII]]
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*[[Cullin 3D structures|Cullin 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Joo, K]]
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[[Category: Joo K]]
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[[Category: Jung, J U]]
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[[Category: Jung JU]]
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[[Category: Kim, Y K]]
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[[Category: Kim YK]]
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[[Category: Ku, B]]
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[[Category: Ku B]]
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[[Category: Kwak, M J]]
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[[Category: Kwak MJ]]
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[[Category: Lee, J]]
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[[Category: Lee J]]
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[[Category: Oh, B H]]
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[[Category: Oh BH]]
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[[Category: Suh, H Y]]
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[[Category: Suh HY]]
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[[Category: Cullin-ring e3 ubiquitin ligase]]
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[[Category: Cytosol]]
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[[Category: Ligase]]
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[[Category: Ubiquitination]]
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Current revision

Structure of the SOCS2-Elongin BC complex bound to an N-terminal fragment of Cullin5

PDB ID 4jgh

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