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1s7m

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[[Image:1s7m.gif|left|200px]]
 
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{{Structure
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==Crystal Structure of HiaBD1==
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|PDB= 1s7m |SIZE=350|CAPTION= <scene name='initialview01'>1s7m</scene>, resolution 2.10&Aring;
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<StructureSection load='1s7m' size='340' side='right'caption='[[1s7m]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1s7m]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S7M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S7M FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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|GENE= hia ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=727 Haemophilus influenzae])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s7m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s7m OCA], [https://pdbe.org/1s7m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s7m RCSB], [https://www.ebi.ac.uk/pdbsum/1s7m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s7m ProSAT]</span></td></tr>
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}}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q48152_HAEIF Q48152_HAEIF]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s7/1s7m_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s7m ConSurf].
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<div style="clear:both"></div>
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'''Crystal Structure of HiaBD1'''
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==See Also==
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*[[Adhesin 3D structures|Adhesin 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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Haemophilus influenzae is an important human pathogen that initiates infection by colonizing the upper respiratory tract. The H. influenzae Hia autotransporter is an adhesive protein that promotes adherence to respiratory epithelial cells. Hia adhesive activity resides in two homologous binding domains, called HiaBD1 and HiaBD2. These domains interact with the same host cell receptor, but bind with different affinities. In this report, we describe the crystal structure of the high-affinity HiaBD1 binding domain, which has a novel trimeric architecture with three-fold symmetry and a mushroom shape. The subunit constituents of the trimer are extensively intertwined. The receptor-binding pocket is formed by an acidic patch that is present on all three faces of the trimer, providing potential for a multivalent interaction with the host cell surface, analogous to observations with the trimeric tumor necrosis factor superfamily of proteins. Hia is a novel example of a bacterial trimeric adhesin and may be the prototype member of a large family of bacterial virulence proteins with a similar architecture.
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==About this Structure==
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1S7M is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S7M OCA].
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==Reference==
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Structural basis for host recognition by the Haemophilus influenzae Hia autotransporter., Yeo HJ, Cotter SE, Laarmann S, Juehne T, St Geme JW 3rd, Waksman G, EMBO J. 2004 Mar 24;23(6):1245-56. Epub 2004 Mar 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15029242 15029242]
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[[Category: Haemophilus influenzae]]
[[Category: Haemophilus influenzae]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Cotter, S E.]]
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[[Category: Cotter SE]]
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[[Category: Geme, J W.St.]]
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[[Category: Juehne T]]
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[[Category: Juehne, T.]]
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[[Category: Laarmann S]]
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[[Category: Laarmann, S.]]
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[[Category: St Geme JW]]
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[[Category: Waksman, G.]]
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[[Category: Waksman G]]
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[[Category: Yeo, H J.]]
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[[Category: Yeo HJ]]
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[[Category: adhesion]]
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[[Category: autotransporter]]
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[[Category: homotrimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:01:30 2008''
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Current revision

Crystal Structure of HiaBD1

PDB ID 1s7m

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