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4lg7
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==Crystal structure MBD4 MBD domain in complex with methylated CpG DNA== | ==Crystal structure MBD4 MBD domain in complex with methylated CpG DNA== | ||
| - | <StructureSection load='4lg7' size='340' side='right' caption='[[4lg7]], [[Resolution|resolution]] 2.50Å' scene=''> | + | <StructureSection load='4lg7' size='340' side='right'caption='[[4lg7]], [[Resolution|resolution]] 2.50Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4lg7]] is a 3 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4lg7]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LG7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LG7 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lg7 OCA], [https://pdbe.org/4lg7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lg7 RCSB], [https://www.ebi.ac.uk/pdbsum/4lg7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lg7 ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MBD4_HUMAN MBD4_HUMAN] Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.<ref>PMID:10097147</ref> <ref>PMID:10930409</ref> | ||
==See Also== | ==See Also== | ||
| - | *[[Methyl CpG binding protein|Methyl CpG binding protein]] | + | *[[Methyl CpG binding protein 3D structures|Methyl CpG binding protein 3D structures]] |
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Arrowsmith CH]] |
| - | [[Category: | + | [[Category: Bountra C]] |
| - | [[Category: | + | [[Category: Edwards AM]] |
| - | [[Category: | + | [[Category: Min J]] |
| - | [[Category: Tempel | + | [[Category: Tempel W]] |
| - | [[Category: Wernimont | + | [[Category: Wernimont AK]] |
| - | [[Category: Xu | + | [[Category: Xu C]] |
| - | + | ||
| - | + | ||
Current revision
Crystal structure MBD4 MBD domain in complex with methylated CpG DNA
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bountra C | Edwards AM | Min J | Tempel W | Wernimont AK | Xu C
