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4k2p

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==The Structure of a Quintuple Mutant of the Tiam1 PH-CC-Ex Domain==
==The Structure of a Quintuple Mutant of the Tiam1 PH-CC-Ex Domain==
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<StructureSection load='4k2p' size='340' side='right' caption='[[4k2p]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
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<StructureSection load='4k2p' size='340' side='right'caption='[[4k2p]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4k2p]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K2P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4K2P FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4k2p]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K2P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4K2P FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.98&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4k2o|4k2o]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TIAM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4k2p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k2p OCA], [https://pdbe.org/4k2p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4k2p RCSB], [https://www.ebi.ac.uk/pdbsum/4k2p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4k2p ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k2p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k2p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4k2p RCSB], [http://www.ebi.ac.uk/pdbsum/4k2p PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TIAM1_HUMAN TIAM1_HUMAN] Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4k2p" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Fuentes, E J]]
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[[Category: Large Structures]]
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[[Category: Gakhar, L]]
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[[Category: Fuentes EJ]]
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[[Category: Joshi, M]]
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[[Category: Gakhar L]]
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[[Category: Par-3]]
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[[Category: Joshi M]]
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[[Category: Ph and coiled coil domain]]
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[[Category: Phosphoinositide binding]]
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[[Category: Protein-protein interaction]]
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[[Category: Signaling protein]]
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[[Category: Tight junction]]
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Current revision

The Structure of a Quintuple Mutant of the Tiam1 PH-CC-Ex Domain

PDB ID 4k2p

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