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4lq8

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==Rickettsia rickettsii cell surface antigen 4 (sca4) head domain (residues 21-360)==
==Rickettsia rickettsii cell surface antigen 4 (sca4) head domain (residues 21-360)==
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<StructureSection load='4lq8' size='340' side='right' caption='[[4lq8]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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<StructureSection load='4lq8' size='340' side='right'caption='[[4lq8]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4lq8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rickettsia_rickettsii Rickettsia rickettsii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LQ8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LQ8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4lq8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rickettsia_rickettsii Rickettsia rickettsii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LQ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LQ8 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3h2u|3h2u]], [[3h2v|3h2v]], [[3smx|3smx]], [[3vf0|3vf0]], [[3zzz|3zzz]], [[3zzy|3zzy]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">sca4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=783 Rickettsia rickettsii])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lq8 OCA], [https://pdbe.org/4lq8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lq8 RCSB], [https://www.ebi.ac.uk/pdbsum/4lq8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lq8 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lq8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lq8 RCSB], [http://www.ebi.ac.uk/pdbsum/4lq8 PDBsum]</span></td></tr>
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</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/B0BXR4_RICRO B0BXR4_RICRO]
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The obligate intracellular, gram-negative bacterium Rickettsia is the causative agent of spotted fevers and typhus in humans. Surface cell antigen (sca) proteins surround these bacteria. We recently reported the colocalization of one of these proteins, sca4, with vinculin in cells at sites of focal adhesions and demonstrated that two vinculin binding sites directed the sca4/vinculin interaction. Here we report the 2.2 A crystal structure of the conserved N-terminal 38 kDa domain of sca4 from Rickettsia rickettsii. The structure reveals two subdomains. The first is an all-helical domain that is folded in a fashion similar to the dimeric assembly chaperone for rubisco, namely RbcX. The following and highly conserved beta-strand domain lacks significant structural similarity with other known structures and to the best of our knowledge represents a new protein fold.
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Crystal structure of the N-terminal domains of the surface cell antigen 4 of Rickettsia.,Lee JH, Vonrhein C, Bricogne G, Izard T Protein Sci. 2013 Jul 31. doi: 10.1002/pro.2322. PMID:23904352<ref>PMID:23904352</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Rickettsia rickettsii]]
[[Category: Rickettsia rickettsii]]
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[[Category: Bricogne, G]]
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[[Category: Bricogne G]]
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[[Category: Izard, T]]
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[[Category: Izard T]]
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[[Category: Lee, J H]]
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[[Category: Lee JH]]
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[[Category: Vonrhein, C]]
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[[Category: Vonrhein C]]
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[[Category: Cell adhesion]]
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Current revision

Rickettsia rickettsii cell surface antigen 4 (sca4) head domain (residues 21-360)

PDB ID 4lq8

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