1se4

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[[Image:1se4.gif|left|200px]]
 
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{{Structure
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==STAPHYLOCOCCAL ENTEROTOXIN B COMPLEXED WITH LACTOSE==
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|PDB= 1se4 |SIZE=350|CAPTION= <scene name='initialview01'>1se4</scene>, resolution 1.9&Aring;
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<StructureSection load='1se4' size='340' side='right'caption='[[1se4]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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|SITE= <scene name='pdbsite=LAC:Lactose+Binding+Site'>LAC</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=LAT:LACTOSE'>LAT</scene>
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<table><tr><td colspan='2'>[[1se4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SE4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SE4 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=PRD_900004:beta-lactose'>PRD_900004</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1se4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1se4 OCA], [https://pdbe.org/1se4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1se4 RCSB], [https://www.ebi.ac.uk/pdbsum/1se4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1se4 ProSAT]</span></td></tr>
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</table>
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'''STAPHYLOCOCCAL ENTEROTOXIN B COMPLEXED WITH LACTOSE'''
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== Function ==
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[https://www.uniprot.org/uniprot/ETXB_STAAU ETXB_STAAU] Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death.
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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The three-dimensional structure of staphylococcal enterotoxin C2 has been determined at 2.7 A resolution by x-ray diffraction, while the structures of enterotoxins A and E have been modelled based on their sequence homology to other staphylococcal enterotoxins. The T-cell receptor-binding sites of staphylococcal enterotoxin (SE) B and SEC2 are compared and the stereochemical interactions likely to be responsible for their differing V beta specificities are identified. A similar comparison is made between SEA and SEE.
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/se/1se4_consurf.spt"</scriptWhenChecked>
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1SE4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SE4 OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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Residues defining V beta specificity in staphylococcal enterotoxins., Swaminathan S, Furey W, Pletcher J, Sax M, Nat Struct Biol. 1995 Aug;2(8):680-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7552730 7552730]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1se4 ConSurf].
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[[Category: Single protein]]
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
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[[Category: Sax, M.]]
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[[Category: Sax M]]
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[[Category: Swaminathan, S.]]
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[[Category: Swaminathan S]]
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[[Category: LAT]]
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[[Category: 3d structure]]
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[[Category: complex]]
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[[Category: lactose]]
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[[Category: seb]]
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[[Category: superantigen]]
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[[Category: toxin]]
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[[Category: x-ray]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:03:44 2008''
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Current revision

STAPHYLOCOCCAL ENTEROTOXIN B COMPLEXED WITH LACTOSE

PDB ID 1se4

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