4lz6

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:55, 20 March 2024) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Structure of MATE multidrug transporter DinF-BH==
==Structure of MATE multidrug transporter DinF-BH==
-
<StructureSection load='4lz6' size='340' side='right' caption='[[4lz6]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
+
<StructureSection load='4lz6' size='340' side='right'caption='[[4lz6]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4lz6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bachd Bachd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LZ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LZ6 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4lz6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Alkalihalobacillus_halodurans_C-125 Alkalihalobacillus halodurans C-125]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LZ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LZ6 FirstGlance]. <br>
-
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4lz9|4lz9]]</td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BH2163 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272558 BACHD])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lz6 OCA], [https://pdbe.org/4lz6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lz6 RCSB], [https://www.ebi.ac.uk/pdbsum/4lz6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lz6 ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lz6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lz6 RCSB], [http://www.ebi.ac.uk/pdbsum/4lz6 PDBsum]</span></td></tr>
+
</table>
</table>
-
<div style="background-color:#fffaf0;">
+
== Function ==
-
== Publication Abstract from PubMed ==
+
[https://www.uniprot.org/uniprot/Q9KAX3_HALH5 Q9KAX3_HALH5]
-
Multidrug and toxic compound extrusion (MATE) transporters contribute to multidrug resistance by coupling the efflux of drugs to the influx of Na(+) or H(+). Known structures of Na(+)-coupled, extracellular-facing MATE transporters from the NorM subfamily revealed 12 membrane-spanning segments related by a quasi-two-fold rotational symmetry and a multidrug-binding cavity situated near the membrane surface. Here we report the crystal structure of an H(+)-coupled MATE transporter from Bacillus halodurans and the DinF subfamily at 3.2-A resolution, unveiling a surprisingly asymmetric arrangement of 12 transmembrane helices. We also identified a membrane-embedded substrate-binding chamber by combining crystallographic and biochemical analyses. Our studies further suggested a direct competition between H(+) and substrate during DinF-mediated transport and implied how a MATE transporter alternates between its extracellular- and intracellular-facing conformations to propel multidrug extrusion. Collectively, our results demonstrated heretofore-unrecognized mechanistic diversity among MATE transporters.
+
-
 
+
-
Structural insights into H(+)-coupled multidrug extrusion by a MATE transporter.,Lu M, Radchenko M, Symersky J, Nie R, Guo Y Nat Struct Mol Biol. 2013 Nov;20(11):1310-7. doi: 10.1038/nsmb.2687. Epub 2013, Oct 20. PMID:24141706<ref>PMID:24141706</ref>
+
-
 
+
-
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+
-
</div>
+
-
== References ==
+
-
<references/>
+
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Bachd]]
+
[[Category: Alkalihalobacillus halodurans C-125]]
-
[[Category: Guo, Y]]
+
[[Category: Large Structures]]
-
[[Category: Lu, M]]
+
[[Category: Guo Y]]
-
[[Category: Nie, R]]
+
[[Category: Lu M]]
-
[[Category: Radchenko, M]]
+
[[Category: Nie R]]
-
[[Category: Symersky, J]]
+
[[Category: Radchenko M]]
-
[[Category: Multidrug transporter]]
+
[[Category: Symersky J]]
-
[[Category: Transport protein]]
+

Current revision

Structure of MATE multidrug transporter DinF-BH

PDB ID 4lz6

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4lz6"
Personal tools