This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4klo

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (16:01, 20 September 2023) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
 +
==DNA polymerase beta matched nick complex with Mg2+ and PPi, 30 min==
==DNA polymerase beta matched nick complex with Mg2+ and PPi, 30 min==
-
<StructureSection load='4klo' size='340' side='right' caption='[[4klo]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
+
<StructureSection load='4klo' size='340' side='right'caption='[[4klo]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4klo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KLO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KLO FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4klo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KLO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KLO FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PPV:PYROPHOSPHATE'>PPV</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.845&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4kld|4kld]], [[4kle|4kle]], [[4klf|4klf]], [[4klg|4klg]], [[4klh|4klh]], [[4kli|4kli]], [[4klj|4klj]], [[4kll|4kll]], [[4klm|4klm]], [[4klp|4klp]], [[4klq|4klq]], [[4kls|4kls]], [[4klt|4klt]], [[4klu|4klu]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PPV:PYROPHOSPHATE'>PPV</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Polb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4klo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4klo OCA], [https://pdbe.org/4klo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4klo RCSB], [https://www.ebi.ac.uk/pdbsum/4klo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4klo ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4klo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4klo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4klo RCSB], [http://www.ebi.ac.uk/pdbsum/4klo PDBsum]</span></td></tr>
+
</table>
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/DPOLB_HUMAN DPOLB_HUMAN] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.<ref>PMID:9207062</ref> <ref>PMID:9572863</ref> <ref>PMID:11805079</ref> <ref>PMID:21362556</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 16: Line 18:
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
 +
<div class="pdbe-citations 4klo" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
-
*[[DNA polymerase|DNA polymerase]]
+
*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
Line 24: Line 27:
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Beard, W A]]
+
[[Category: Large Structures]]
-
[[Category: Freudenthal, B D]]
+
[[Category: Beard WA]]
-
[[Category: Shock, D D]]
+
[[Category: Freudenthal BD]]
-
[[Category: Wilson, S H]]
+
[[Category: Shock DD]]
-
[[Category: Dna polymerase]]
+
[[Category: Wilson SH]]
-
[[Category: Lyase-dna complex]]
+
-
[[Category: Transferase]]
+

Current revision

DNA polymerase beta matched nick complex with Mg2+ and PPi, 30 min

PDB ID 4klo

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4klo"
Personal tools